지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 171 - 193 (23page)
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초록· 키워드
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Aging has been associated with both cerebral blood flow (CBF) reductions and structural changes, particularly in the medial temporal lobe (MTL) region. However, it remains unclear whether the decline of CBF in the MTL is due entirely or just partially to anatomical changes. In the present study, pseudocontinuous arterial spin labeling (ASL) was used to measure quantitative CBF in forty-one healthy older adults. High-resolution T1-weighted structure images were also acquired from each subject. Robust age-related CBF decline and anatomical changes were observed in the medial and superior temporal lobe. After controlling for partial volume effect (PVE) and brain atrophy, there were still significant age-related regional CBF decreases in the right parahippocampus and the bilateral insula. However, regional CBF in the left parahippocampal gyrus was not correlated with age after PVE correction. Our results support the importance of structural correction for regional CBF quantification in aging populations and suggest that anatomical changes alone cannot explain the regional CBF decline in older adults.
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참고문헌 (25)
참고문헌 신청
Adinoff, B. / 2006 / Sex differences in medial and lateral orbitofrontal cortex hypoperfusion in cocaine-dependent men and women / Gender Medicine 3 : 206 ~ 222
Akiyama, H. / 1997 / Normal human aging: factors contributing to cerebral atrophy / Journal of the Neurological Sciences 152 : 39 ~ 49
Alsop, D.C. / 2008 / Hippocampal hyperperfusion in Alzheimer’s disease / Neuroimage 42 : 1267 ~ 1274
Alsop, D.C. / 2010 / Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer’s disease / Journal of Alzheimer’s Disease 20 : 871 ~ 880
Asllani, I. / 2008 / Regression algorithm correcting for partial volume effects in arterial spin labeling MRI / Magnetic Resonance in Medicine 60 : 1362 ~ 1371
Akiyama, H. / 1997 / Normal human aging: factors contributing to cerebral atrophy / Journal of the Neurological Sciences 152 : 39 ~ 49
Alsop, D.C. / 2008 / Hippocampal hyperperfusion in Alzheimer’s disease / Neuroimage 42 : 1267 ~ 1274
Alsop, D.C. / 2010 / Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer’s disease / Journal of Alzheimer’s Disease 20 : 871 ~ 880
Asllani, I. / 2008 / Regression algorithm correcting for partial volume effects in arterial spin labeling MRI / Magnetic Resonance in Medicine 60 : 1362 ~ 1371
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