지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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The role of Fatty acid binding protein 4 (FABP4) gene is critical for lipid metabolism and for maintaining homeostasis in adipocytes. Association between Hanwoo carcass traits and FABP4 gene g.7516G>C SNP has been reported previously, however, its association and how does it influence Korean brindle and black cattle has not been demonstrated and established till date. For this purpose, the study was planned to analyze the SNP association (Single Nucleotide Polymorphism) (g.7516G>C) in FABP4 gene and gather genetic information on economic traits of Korean brindle cattle and black cattle. As per sequence of bovine FABP4 gene available (Genbank accession No. NC_007312.4), one pair of primers (5’-ATA TAG TCC ATA GGG TGG CAA AGA-3’ and 5’-AAC CTC TCT TTG AAT TCT CCA TTC T-3’) was designed to amplify a 452bp product of the FABP4 gene including the region of 7417–7868. The SNP, detected by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) methods using restriction enzyme MspA1I, was genotyped in 117 animals of brindle cattle and 24 animals of black cattle population. Statistical analysis revealed that the FABP4 genotype significantly (p<0.05) affect with carcass weight, but there was no significant association with any other economic traits was observed in brindle as well as in black cattle. In conclusion, these results suggested that SNP (g.7516G>C), located in FABP4 gene, could be used as important DNA marker of economic traits in Korean brindle cattle. Furthermore, we suggest that additional samples needs to further analysed to make related data exclusively authentic.
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참고문헌 (10)
참고문헌 신청
Casas, E. / 2003 / Detection of quantitative trait loci for growth and carcass composition in cattle / J. Anim. Sci 81 : 2976 ~ 2983
Damcott, C. M. / 2004 / Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and
Jiang, Z. / 1999 / Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds / Mammalian Genome 10 : 191 ~ 193
Kim, D. H. / 2008 / The Identification of single nucleotide polymorphism (SNP) related to economic traits in Hanwoo / 석사 / Kangwon National University
Marshall, T. C. / 1998 / Statistical confidence for likelihood-based paternity inference in natural populations / Mol. Ecol 7 : 639 ~ 655
Damcott, C. M. / 2004 / Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and
Jiang, Z. / 1999 / Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds / Mammalian Genome 10 : 191 ~ 193
Kim, D. H. / 2008 / The Identification of single nucleotide polymorphism (SNP) related to economic traits in Hanwoo / 석사 / Kangwon National University
Marshall, T. C. / 1998 / Statistical confidence for likelihood-based paternity inference in natural populations / Mol. Ecol 7 : 639 ~ 655
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