지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Streptococcus mutans (S. mutans) is the major causative bacteria in dental caries. Xylitol is effective anticarious natural sugar substitute by inhibiting the virulence of S. mutans. However, long-term xylitol consumption leads to the emergence of the xylitol-resistant (XR) strains which means xylitol is no more inhibited their growth. We therefore confirmed the general characteristics and the virulence factors of the xylitol-sensitive (XS) and XR S. mutans for different concentrations of xylitol. S. mutans KCTC 3065 was maintained in TYE medium containing 0.4% glucose with 1%xylitol during 30 days at 37℃, 10% CO_2 to form XR strain. The strains were transferred to new medium every 24 hr and the same procedures without xylitol were repeated for the formation of XS S. mutans. Both XS and XR were cultured in different concentrations of xylitol (0%, 0.1% and 1%) then, cell growth, acid production and mRNA expression of gtf genes were analyzed. Xylitol reduced the cell growth of XS S. mutans in dose-dependent manner, but not reduced that of XR. Xylitol inhibited acid production of XS in dose-dependent manner, but not inhibited that of XR. Xylitol reduced the gtfB and gtfD mRNA expression of XS S. mutans which genes synthesized soluble and insoluble extracellular polysaccharides, but not reduced that of XR. These results indicate that the virulence of XR S. mutans is different characters of XS strains, which suggests XR strains may have different cariogenicity of XS strains. Further study is needed to explain the mechanism related to extracellular polysaccharide in the XR strains.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
[학술지(정기간행
Assev S / 1980 / Growth inhibition of Streptococcus mutans strain OMZ 176 by xylitol / Acta Pathol Microbiol Scand 88 (1) : 61 ~ 63
Assev S / 1986 / Further studies in the growth inhibition of Streptococcus mutans OMZ176 by xylitol / Acta Pathol Microbiol Immunol Scand 94 (2) : 97 ~ 102
Beckers HJ / 1988 / Influence of xylitol on growth,establishment,and cariogenicity of Streptococcus mutans in dental plaque of rats / Caries Res 22 (3) : 166 ~ 173
Ebisu S / 1974 / The structure of water-insoluble glucans of cariogenic Streptococcus mutans,formed in the absence and presence of dextranase / Carbohydr Res 38 : 374 ~ 381
Assev S / 1980 / Growth inhibition of Streptococcus mutans strain OMZ 176 by xylitol / Acta Pathol Microbiol Scand 88 (1) : 61 ~ 63
Assev S / 1986 / Further studies in the growth inhibition of Streptococcus mutans OMZ176 by xylitol / Acta Pathol Microbiol Immunol Scand 94 (2) : 97 ~ 102
Beckers HJ / 1988 / Influence of xylitol on growth,establishment,and cariogenicity of Streptococcus mutans in dental plaque of rats / Caries Res 22 (3) : 166 ~ 173
Ebisu S / 1974 / The structure of water-insoluble glucans of cariogenic Streptococcus mutans,formed in the absence and presence of dextranase / Carbohydr Res 38 : 374 ~ 381
이 논문의 저자 정보
최근 본 자료
댓글(0)
0