지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
이 논문의 연구 히스토리 (3)
2015
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Acaiberry (Euterpe oleracea Mart.) is widely diffused in amazon and is known that has high antioxidant capacity and potential anti-inflammatoryactivities. The aim of this study was to evaluate analgesic effects of acaiberry in formalin-induced orofacial pain through p38 mitogen-activatedprotein kinases (p38 MAPK) and nicotinamide adenine dinucleotide phosphate 4 (NOX4) pathway. Rats were divided into 5 groups (n=6); formalin(5%, 50 μL), formalin after saline (vehicle) or acaiberry (16, 80, 160 mg/kg, intraperitoneally). The nociceptive response was investigated all ofgroups, p38 MAPK or NOX4 were analysed at dose of 80 mg/kg of acaiberry in rat’s medulla oblongata and adrenal gland. Results indicated thatacai berry produced analgesic effect in a dose-dependent manner and significantly reduced formalin-induced nociceptive response at 15∼40 min.
Acaiberry (80 mg/kg) decreased the increased p38 MAPK activation and NOX4 expression in medulla oblongata and adrenal gland. Based on theseresults, acaiberry is believed to be useful for modulation of orofacial pain and its treatments because of its anti-inflammatory and antioxidative effects.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
[학술지(
Altenhofer S / 2012 / The NOX toolbox: validating the role of NADPH oxidases in physiology and disease / Cell Mol Life Sci 69 : 2327 ~ 2343
Chen F / 2012 / From form to function: the role of Nox4 in the cardiovascular system / Front Physiol 3 : 412 ~
Chiang HM / 2014 / Sesamin reduces acute hepatic injury induced by lead coupled with lipopolysaccharide / J Chin Med Assoc 77 : 227 ~ 233
Choi HS / 2003 / Effects of intracisternal injection of interleukin-6 on nociceptive jaw opening reflex and orofacial formalin test in freely moving rats / Brain Res Bull 59
Altenhofer S / 2012 / The NOX toolbox: validating the role of NADPH oxidases in physiology and disease / Cell Mol Life Sci 69 : 2327 ~ 2343
Chen F / 2012 / From form to function: the role of Nox4 in the cardiovascular system / Front Physiol 3 : 412 ~
Chiang HM / 2014 / Sesamin reduces acute hepatic injury induced by lead coupled with lipopolysaccharide / J Chin Med Assoc 77 : 227 ~ 233
Choi HS / 2003 / Effects of intracisternal injection of interleukin-6 on nociceptive jaw opening reflex and orofacial formalin test in freely moving rats / Brain Res Bull 59
이 논문의 저자 정보
최근 본 자료
댓글(0)
0