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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Over expression of TGF-β1 revealed the same phenotype as NFI-C deficient mouse. It has been reported that NFI-C deficient mice demonstrated abnormal odontoblast differentiation and aberrant dentin formation during root development. In the present study, in order to investigate the histological differences between wild type (WT) mouse and NFI-C deficient mouse, we compared morphological characteristics and smad4 expression between those mice.
Hematoxyline-eosin (H-E) staining was used to investigate morphological changes and immunohistochemistry was also performed to observe the Smad4 expression pattern. In H-E staining, incisor of NFI-C deficient mouse showed an open area in the lingual root, irregular odontoblasts and osteodentin. Also, NFI-C deficient mouse showed short root and osteodentin in molar. In addition, Smad4 protein was strongly expressed in NFI-C deficient mouse compared with wild type. These findings suggest that NFI-C deficiency affects odontoblast differentiation and result in the formation of abnormal roots. Therefore, balancing between NFI-C and TGF-β signaling including Smad4 is important for the regulation of normal odontoblast differentiation and dentin formation.
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참고문헌 (21)
참고문헌 신청
Antonio Nanci / 2007 / Ten cate’s oral histology: Development, structure, and function. 7th ed / MOSBY : 89 ~ 103
Aristidis M / 2001 / Smad regulation in TGF-β signal transduction / J Cell Sci 114 (24) : 4363 ~ 4366
Bosshardt DD / 2004 / Hertwig's epithelial root sheath matrix proteins and initiation of cemetogenesis in porcine teeth / J Periodontal 31 (3) : 184 ~ 192
Bruce Alberts / 2008 / Molecular biology of the cell. 5th ed / Garland Science : 393 ~ 940
Chaudhry AZ / 1997 / Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development / Dev Dye 208 (3) : 313 ~ 325
Aristidis M / 2001 / Smad regulation in TGF-β signal transduction / J Cell Sci 114 (24) : 4363 ~ 4366
Bosshardt DD / 2004 / Hertwig's epithelial root sheath matrix proteins and initiation of cemetogenesis in porcine teeth / J Periodontal 31 (3) : 184 ~ 192
Bruce Alberts / 2008 / Molecular biology of the cell. 5th ed / Garland Science : 393 ~ 940
Chaudhry AZ / 1997 / Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development / Dev Dye 208 (3) : 313 ~ 325
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