지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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We investigated the genotoxicity of two chemicals, methylcyclopentane and 1,4-dichlorobutane with in vivo micronucleus test. Although these two chemicals have already been tested many times, a micronucleus test has not been conducted and the usage of these chemicals has been recently increased. 7 week male ICR mice were tested at dosages of 500, 1,000, and 2,000 mg/kg for methylcyclopentane and 500, 1,000, and 2,000 mg/kg for 1,4-dichlorobutane, respectively. After 24 hours of oral administration with the two chemicals, the mice were sacrificed and their bone marrow cells were prepared for smearing slides. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes (PCE), all treated groups expressed no statistically significant increase of MNPCE compared to the negative control group. There were no clinical signs related with the oral exposure of these two chemicals. It was concluded that the two chemicals did not induce micronucleus in the bone marrow cells of ICR mice, and there was no direct proportion with dosage. These results indicate that the two chemicals have no mutagenic potential under each study condition.
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참고문헌 (16)
참고문헌 신청
Coleman EC / 1981 / Isolation and identification of volatile compounds from baked potatoes / J Agric Food Chem 29 : 42 ~ 48
Conkle JP / 1975 / Trace composition of human respiratory gas / Arch Environ Health 30 : 290 ~ 295
Douglas GR / 1985 / How well do in vitro tests predict in vivo genotoxicity / Environ Mutagen 7 (3) : 31 ~
Fenech M / 1994 / Sex is an important variable affecting spontaneous micronucleus frequency in cytokinesisblocked lymphocytes / Mutat Res 313 : 203 ~ 207
Grandjean P / 2006 / Developmental neurotoxicity of industrial chemicals / Lancet 16 (368) : 2167 ~ 2178
Conkle JP / 1975 / Trace composition of human respiratory gas / Arch Environ Health 30 : 290 ~ 295
Douglas GR / 1985 / How well do in vitro tests predict in vivo genotoxicity / Environ Mutagen 7 (3) : 31 ~
Fenech M / 1994 / Sex is an important variable affecting spontaneous micronucleus frequency in cytokinesisblocked lymphocytes / Mutat Res 313 : 203 ~ 207
Grandjean P / 2006 / Developmental neurotoxicity of industrial chemicals / Lancet 16 (368) : 2167 ~ 2178
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