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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.8
- 수록면
- 198 - 206 (9page)
- DOI
- 10.15188/kjopp.2019.08.33.4.198
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초록· 키워드
오류제보하기
This study was conducted to evaluate the vasorelaxant effect of DangGuiSu-San and SamHwangSaSim-Tang extract on contracted rabbit carotid artery. To study the effect of DangGuiSu-San and SamHwangSaSim-Tang extract on contracted rabbit carotid arterial strips, arterial strips with intact or damaged endothelium were used for experiment using organ bath. The pre-contracted arterial strips with Phenylephrine(PE) was treated with various concentrations of DangGuiSu-San and SamHwangSaSim-Tang extract(0.01, 0.03, 0.1, 0.3 and 1.0 ㎎/㎖). To determine the mechanisms of DangGuiSu-San and SamHwangSaSim-Tang-induced vasorelaxant, DangGuiSu-San and SamHwangSaSim-Tang extract were infused into contracted arterial rings which had been pretreated by indomethacin(IM), tetraethylammonium chloride(TEA), Nω-nitro-L-arginine (<SUB>L</SUB>-NNA), methylene blue(MB). And calcium chloride(Ca) 1 mM was infused into precontracted arterial ring induced by PE after treatment of DangGuiSu-San and SamHwangSaSim-Tang extract in Ca<SUP>2+</SUP>-free krebs solution. DangGuiSu-San and SamHwangSaSim-Tang extract revealed significant relaxation on PE-induced arterial contraction. DangGuiSu-San and SamHwangSaSim-Tang extract also had an effective relaxation to the intact endothelium arterial ring. SamHwangSaSim-Tang extract on contracted rabbit carotid artery is related with NO-cGMP pathway. Pretreatment of DangGuiSu-San and SamHwangSaSim-Tang extract inhibited the contraction by influx of extracellular Ca<SUP>2+</SUP> in contracted arterial ring induced by NE. This study indicated that the relaxation effect of SamHwangSaSim-Tang extract on contracted rabbit carotid artery is related with NO-cGMP pathway. Pretreatment of DangGuiSu-San and SamHwangSaSim-Tang extract inhibited the contraction by influx of extracellular Ca<SUP>2+</SUP> in contracted arterial ring induced by NE
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (29)
참고문헌 신청
Shin HG / 2018 / Standard herbal medicine formulary / KIOM :163~171
Heo J. / 1983 / Donguibogam / Namsandang :581
여남회 / 2002 / 당귀수산(當歸鬚散) 투여가 타박부상된 흰쥐의 혈액 효소활성도에 미치는 영향 / 한국체육학회지 41(3):333~340
Lee GH / 1999 / Study on the Effects of Dangguixusan on Experimental Blood Stasis Model Induced by Compression / Graduate School Kyung Hee University 22(1):22~38
Wei CH / 2013 / Clinical Observation on 40 Cases of Acute Pulmonary Contusion Treated by Danggui Xu Powder / Modern medical and health 29(12):1768~1769
Heo J. / 1983 / Donguibogam / Namsandang :581
여남회 / 2002 / 당귀수산(當歸鬚散) 투여가 타박부상된 흰쥐의 혈액 효소활성도에 미치는 영향 / 한국체육학회지 41(3):333~340
Lee GH / 1999 / Study on the Effects of Dangguixusan on Experimental Blood Stasis Model Induced by Compression / Graduate School Kyung Hee University 22(1):22~38
Wei CH / 2013 / Clinical Observation on 40 Cases of Acute Pulmonary Contusion Treated by Danggui Xu Powder / Modern medical and health 29(12):1768~1769
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