지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 125 - 129 (5page)
- DOI
- 10.17519/apiculture.2019.06.34.2.125
이용수
초록· 키워드
오류제보하기
Honey bees are important pollinators in agriculture, but are threatened by the pathogen Ascosphaera apis , which causes chalkbrood. Despite attempts to control this fungus using synthetic fungicides, none of them have been proven to be completely effective. Among 640 natural compounds that we tested, 4-hydroxyderricin (MIC=3.125, 6.25 mg/L after 24 h and 48 h growth, respectively) exhibited the strongest anti- Ascosphaera apis activity, followed by acetylshikonin (MIC=12.5 mg/L for 24 h and 48 h growth). 4-Hydroxyderricin showed selective growth inhibition of Ascosphaera apis and Rhizopus oryzae among tested fungus strains. Treatment 4-hydroxyderricin with miconazole revealed a synergistic effect (FICI=0.65±0.13 at 48 h incubation). These findings suggest that 4-hydroxyderricin, which has antifungal activity against Ascosphaera apis but few other fungal species, can effectively control infectious fungal diseases. Combined treatment of bees with 4-hydroxyderricin and miconazole could reduce cytotoxicity and improve the cost effectiveness of treatment.
목차
Abstract
INTRODUCTION
MATERIAL AND METHODS
RESULTS AND DISCUSSION
LITERATURE CITED
참고문헌 (12)
참고문헌 신청
Aronstein, K. A. / 2010 / Chalkbrood disease in honey bees / J. Invertebr. Pathol 103:S20~S29
Battenberg, O. A. / 2013 / Target profiling of 4-Hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification / Mol. Biosyst 9:343~351
Bax, R. / 2015 / Antibiotics: the changing regulatory and pharmaceutical industry paradigm / J. Antimicrob. Chemother 70:1281~1284
조석철 / 2015 / Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity / Biomolecules & Therapeutics 23(5):428~433
Hedtke, K. / 2011 / Evidence for emerging parasites and pathogens influencing outbreaks of stress-related diseases like chalkbrood / J. Invertebr. Pathol 108:167~173
Battenberg, O. A. / 2013 / Target profiling of 4-Hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification / Mol. Biosyst 9:343~351
Bax, R. / 2015 / Antibiotics: the changing regulatory and pharmaceutical industry paradigm / J. Antimicrob. Chemother 70:1281~1284
조석철 / 2015 / Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity / Biomolecules & Therapeutics 23(5):428~433
Hedtke, K. / 2011 / Evidence for emerging parasites and pathogens influencing outbreaks of stress-related diseases like chalkbrood / J. Invertebr. Pathol 108:167~173
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UCI(KEPA) : I410-ECN-0101-2019-527-000882078