지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 165 - 174 (10page)
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초록· 키워드
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Background: Traditional plant drugs, are less toxic and free from side effects compared to general synthetic drugs. They have been used for the treatment of diabetes and associated renal damage. In this study, we evaluated effect of Hachimi-jio-gan against diabetic renal damage in a rat model of type 1 diabetic nephropathy induced by subtotal nephrectomy plus streptozotocin (STZ) injection, and in Otsuka Long-Evans Tokushima Fatty (OLETF) rats and db/db mice as a model of human type 2 diabetes, and its associated complications. To explore the active components of Hachimi-jio-gan, the antidiabetic effect of corni fructus, a consituent of Hachimi-jio-gan, and 7-O-galloyl-D-sedoheptulose, a phenolic compound isolated from corni fructus, were investigated.Methods and Results: We conducted an extensive literature search, and all required data were collected and systematically organized. The findings were reviewed and categorized based on relevance to the topic. A summary of all the therapeutic effects were reported as figures and tables.Conclusions: Hachimi-jio-gan serves as a potential therapeutic agent to against the development of type 1 and type 2 diabetic nephropathy. From the results of characterization active components of corni fructus, 7-O-galloyl-D-sedoheptulose is considered to play an important role in preventing and/or delaying the onset of diabetic renal damage. 7-O-Galloyl-D-sedoheptulose is expected to serve as a novel therapeutic agent against the development of diabetic nephropathy.
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등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Adler S / 1997 / Structure-function relationships in diabetic nephropathy : Lessons and limitations / Kidney International 60:S42~S45
Babior BM / 2002 / The neutrophil NADPH oxidase / Archives of Biochemistry and Biophysics 397:342~344
Bell DSH / 1991 / Diabetic nephropathy : Changing concepts of pathogenesis and treatment / The American Journal of the Medical Sciences 301:195~200
Brenner BM / 2001 / RENAAL Study Investigators: Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy / N Engl J Med 345:861~869
Brownlee M / 1984 / Nonenzymatic glycosylation and the pathogenesis of diabetic complications / Annals of Internal Medicine 101:527~537
Babior BM / 2002 / The neutrophil NADPH oxidase / Archives of Biochemistry and Biophysics 397:342~344
Bell DSH / 1991 / Diabetic nephropathy : Changing concepts of pathogenesis and treatment / The American Journal of the Medical Sciences 301:195~200
Brenner BM / 2001 / RENAAL Study Investigators: Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy / N Engl J Med 345:861~869
Brownlee M / 1984 / Nonenzymatic glycosylation and the pathogenesis of diabetic complications / Annals of Internal Medicine 101:527~537
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UCI(KEPA) : I410-ECN-0101-2019-480-000585361