지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background : Irregular meals and insufficient exercise are major modern lifestyle-related risk factors for constipation. This study aimed to examine the effects of the aqueous extract of Dendrobium speciosum var. (DM) on the improvement of intestinal function and prevention of constipation in rats.
Methods and Results : Constipation in rat was induced by loperamide (4 ㎎/㎏) injection for 5 days and rats were randomly assigned to the following groups: normal control rats (NOR), constipated rats (LOP induced) and constipated rats supplemented with dulcolax-S (POS), DMSG, 100 ㎎/㎏ (DMSG-100), 300 ㎎/㎏ (DMSG-300) and 500 ㎎/㎏ (DMSG-500). The DMSG groups showed increments in the frequency and amount of stools compared to the LOP group. Loperamide treatment markedly reduced the water content of feces, whereas DMSG administration significantly increased fecal water contents. Moreover, DMSG improved intestinal transit speed in constipated-rats. Alcian blue staining revealed increased mucus production by crypt cells and mucus contents in feces and the mucosal surface.
Conclusions : In summary, DM extraction significantly improves intestinal function in rats, which indicates the effectiveness of this extract in the prevention and treatment of constipation.
목차
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참고문헌 (26)
참고문헌 신청
Aichbichler BW / 1998 / A comparison of stool characteristic from normal and constipated people / Digestive Diseases and Sciences 43:2353~2362
Bongers MEJ / 2009 / Health-related quality of life in young adults with symptoms of constipation continuing from childhood into adulthood / Health and Quality of Life Outcomes 7:20
Cepinskas G / 1993 / Adaptive cytoprotection in the small intestine : Role of mucus / American Journal of Physiology 264:G921~G927
Choi JS / 2014 / Laxative effects of fermented rice extract in rats with loperamide-induced constipation / Experimental and Therapeutic Medicine 8:1847~1854
Holzer P. / 2009 / Opioid receptors in the gastrointestinal tract / Regulatory Peptides 155:11~17
Bongers MEJ / 2009 / Health-related quality of life in young adults with symptoms of constipation continuing from childhood into adulthood / Health and Quality of Life Outcomes 7:20
Cepinskas G / 1993 / Adaptive cytoprotection in the small intestine : Role of mucus / American Journal of Physiology 264:G921~G927
Choi JS / 2014 / Laxative effects of fermented rice extract in rats with loperamide-induced constipation / Experimental and Therapeutic Medicine 8:1847~1854
Holzer P. / 2009 / Opioid receptors in the gastrointestinal tract / Regulatory Peptides 155:11~17
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UCI(KEPA) : I410-ECN-0101-2019-480-000587072