지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.8
- 수록면
- 276 - 288 (13page)
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초록· 키워드
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The six polysaccharide fractions were prepared by chromatographic procedure from the hot water extractsof the aboveground parts of Astragalus membranaceus. These six polysaccharides from aboveground parts of Astragalusmembranaceus Bunge were tested for gut-mucosal immune activity and acute toxicity. In a view of molecular weight, the sixfractions were estimated to be 75000, 88000, 129000 and 345000 Da, respectively. Component sugar analysis indicated thatthese fractions were mainly consisted of galactose (46.3 ~ 11.8%) and arabinose (35.4 ~ 9.9%) in addition to glucose,rhamnose, fucose, arabinose, xylose, mannose, glucuronic acid and galacturonic acid. Among the six major purifiedpolysaccharides, AMA-1-b-PS2 showed highest bone merrow cell proliferation and lymphocyte of Peyer's patch stimulatingactivity. It may be concluded that intestinal immune system modulating activity of aboveground parts from Astragalusmembranaceus Bunge is caused by polysaccharides having a polygalacturonan moiety with neutral sugars such as arabinoseand galactose. In single oral dose toxicity study, no differences were observed between control and treated groups in clinicalsigns. The results indicated that lethal dose 50 (LD50) of water extracts from Astragalus membranaceus-aboveground partswas found to be higher than 5000 ㎎/㎏/day in this experiment. From the above results, we may suggest that Astragalusmembranaceus-aboveground parts might have useful as a safe material for functional food and pharmaceutics.
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참고문헌 (41)
참고문헌 신청
Bacic A / 1996 / Porland Press / Porland Press :91~92
Borchers AT / 2000 / Shosaiko-to and other Kampo(Japanese herbal) medicines: A review of their immunomodulatory activities / Journal of Ethnopharmacology 73:1~13
Charles AJ / 1994 / Immunobiology(Part Ⅴ) / Garland Publishing Company :34~56
최명진 / 2010 / 발효 옻 추출물의 생리활성 및 단회 경구 투여 독성시험 / 대한수의학회지 50(3):187~195
Goldstein IJ / 1965 / Methods in carbohydrate chemistry(Vol. 5) / Academic Press :361~370
Borchers AT / 2000 / Shosaiko-to and other Kampo(Japanese herbal) medicines: A review of their immunomodulatory activities / Journal of Ethnopharmacology 73:1~13
Charles AJ / 1994 / Immunobiology(Part Ⅴ) / Garland Publishing Company :34~56
최명진 / 2010 / 발효 옻 추출물의 생리활성 및 단회 경구 투여 독성시험 / 대한수의학회지 50(3):187~195
Goldstein IJ / 1965 / Methods in carbohydrate chemistry(Vol. 5) / Academic Press :361~370
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