지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Alzheimer"s disease (AD) is highly prevalent in dementia, with no specifically effective treatment having yet been discovered. Amyloid plaques are one of the key hallmarks of AD. Transgenic mouse models exhibiting Alzheimer"s disease-like pathology have been widely used to study the pathophysiology of Alzheimer"s disease. In this study, we showed an age-dependent correlation between cognitive function, pathological findings, and [F-18] Florbetaben (FBB) PET images. Nineteen transgenic mice (12 with AD, 7 with controls) were used for this study. We observed an increase in β-Amyloid deposition (Aβ) in brain tissue and [F-18] FBB amyloid PET imaging in the AD group. The [F-18] FBB data showed a mildly negative trend with cognitive function. Pathological findings were negatively correlated with cognitive functions. These finding suggests that amyloid beta deposition can be well-monitored with [F-18] FBB PET and a decline in cognitive function is related to the increase in amyloid plaque burden.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Aizenstein HJ / 2008 / Frequent amyloid deposition without significant cognitive impairment among the elderly / Archives of Neurology 65:1509~1517
Ashe KH / 2001 / Learning and memory in transgenic mice modeling alzheimer's disease / Learning & Memory 8:301~308
Chapman PF / 1999 / Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice / Nature Neuroscience 2:271
Chatziioannou AF / 2002 / Pet scanners dedicated to molecular imaging of small animal models / Molecular Imaging & Biology 4:47~63
Choi GE / 2018 / Autophagy deficiency in myeloid cells exacerbates eosinophilic inflammation in chronic rhinosinusitis / Journal of Allergy and Clinical Immunology 141:938~950.e912
Ashe KH / 2001 / Learning and memory in transgenic mice modeling alzheimer's disease / Learning & Memory 8:301~308
Chapman PF / 1999 / Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice / Nature Neuroscience 2:271
Chatziioannou AF / 2002 / Pet scanners dedicated to molecular imaging of small animal models / Molecular Imaging & Biology 4:47~63
Choi GE / 2018 / Autophagy deficiency in myeloid cells exacerbates eosinophilic inflammation in chronic rhinosinusitis / Journal of Allergy and Clinical Immunology 141:938~950.e912
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UCI(KEPA) : I410-ECN-0101-2019-510-000546487