지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 341 - 348 (8page)
이용수
초록· 키워드
오류제보하기
The polyherbal drug Gyeongshingangjeehwan 18 (GGEx18) from Rheum palmatum L. (Polygonaceae), Laminaria japonica Aresch (Laminariaceae), and Ephedra sinica Stapf (Ephedraceae) has traditionally been used as an antiobesity drug in Korean local clinics. This study investigates the effects of GGEx18 on pancreatic fibroinflammation in high-fat diet (HFD)-fed obese C57BL/6J mice and the molecular mechanism involved in this process. After HFD-fed obese C57BL/6J mice were treated with GGEx18 (125, 250, and 500 mg/kg) for 12 weeks, variables and determinants of obesity, pancreatic inflammation, and fibrosis were measured using histology, immunohistochemistry, and real-time polymerase chain reaction. Administration of GGEx18 at 500 mg/kg/day to obese mice decreased body weight gain, mesenteric adipose tissue mass, and adipocyte size. GGEx18 treatment not only reduced mast cells and CD68-immunoreactive cells, but also decreased collagen levels and α-smooth muscle actin-positive cells in the pancreas of HFD-fed mice. Concomitantly, GGEx18 decreased the expression of genes for inflammation (i.e., CD68 and tumor necrosis factor α) and fibrosis (i.e., collagen α1 and transforming growth factor β) in the pancreas of obese mice. These results suggest that GGEx18 may inhibit visceral obesity and related pancreatic fibroinflammation in HFD-fed obese mice.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Acharya C / 2014 / Role of pancreatic fat in the outcomes of pancreatitis / Pancreatology 14 : 403 ~ 408
[학술지(정기간행물)] - Cao Y / 2014 / Epigallocatechin gallate prevents inflammation by reducing macrophage infiltration and inhibiting tumor necrosis factor-αsignaling in the pancreas of rats on a high-fat diet / Nutrition Research 34 : 1066 ~ 1074
[학술지(정기간행물)] - Chen KK / 1928 / A comparative study of synthetic and natural ephedrines / The Journal of Pharmacology and Experimental Therapeutics 33 : 237 ~ 258
[학술지(정기간행물)] - Duan LF / 2017 / Dachaihu decoction ameliorates pancreatic fibrosis by inhibiting macrophage infiltration in chronic pancreatitis / World Journal of Gastroenterology 23 : 7242 ~ 7252
[학술지(정기간행물)] - Fernandes-Santos C / 2009 / Rosiglitazone aggravates nonalcoholic Fatty pancreatic disease in C57BL/6 mice fed high-fat and high-sucrose diet / Pancreas 38 : e80 ~ e86
[학술지(정기간행물)] - Cao Y / 2014 / Epigallocatechin gallate prevents inflammation by reducing macrophage infiltration and inhibiting tumor necrosis factor-αsignaling in the pancreas of rats on a high-fat diet / Nutrition Research 34 : 1066 ~ 1074
[학술지(정기간행물)] - Chen KK / 1928 / A comparative study of synthetic and natural ephedrines / The Journal of Pharmacology and Experimental Therapeutics 33 : 237 ~ 258
[학술지(정기간행물)] - Duan LF / 2017 / Dachaihu decoction ameliorates pancreatic fibrosis by inhibiting macrophage infiltration in chronic pancreatitis / World Journal of Gastroenterology 23 : 7242 ~ 7252
[학술지(정기간행물)] - Fernandes-Santos C / 2009 / Rosiglitazone aggravates nonalcoholic Fatty pancreatic disease in C57BL/6 mice fed high-fat and high-sucrose diet / Pancreas 38 : e80 ~ e86
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UCI(KEPA) : I410-ECN-0101-2019-510-000302823