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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 2,120 - 2,129 (10page)
- DOI
- 10.13000/JFMSE.2018.12.30.6.2120
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초록· 키워드
오류제보하기
Oxytetracycline (OTC) is a tetracycline broad-specturm antibiotic with bacteriostatic action. The pharmacokinetic properties and the residue level of OTC were studied after dipping to cultured rock fish, (283±5 g) Sebastes schlegelii. For pharmacokinetic studies, OTC of 50, 100 and 400ppm were administered at 15±1℃ and OTC concentrations were determined in plasma, muscle and liver by HPLC-DAD. Plasma, muscle and liver samples were taken at 0.5, 1, 3, 6, 12, 24, 48, 168 and 336h post-injection. The kinetic profiles of OTC were analyzed by fitting to a two-compartmental model. The kinetic profile of the OTC was found to be dose dependent. The time for maximum concentration (T<SUB>max</SUB>) and the maximum concentration (C<SUB>max</SUB>) of 400ppm OTC were 2.12h at 1.66㎍/㎖ in plasma, 15.25h at 0.95㎍/㎖ in muscle, and 15.3h at 6.29㎍/㎖ in liver. The absorption half-life (t<SUB>1/2</SUB>α) of 400ppm OTC was 1.24h in plasma, 9.43h in muscle, and 10.31h in liver, respectively, whereas the elimination half-life (t<SUB>1/2</SUB>β) of the drug was 90.28h in plasma, 265.3h in muscle, and 6.93 ×105h in liver. A higher OTC residue level of liver in comparison with muscle and plasma was showed at all time points
목차
Abstract
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
References
참고문헌 (21)
참고문헌 신청
[학술지(정기간행물)] - Harry Björklund / 1990 / Temperature-related absorption and excretion of oxytetracycline in rainbow trout (Salmo gairdneri R.) / Aquaculture 84 (3-4) : 363 ~ 372
[인터넷자원] - Food and drug administration / / Guidance for Industry Bioanalytical Method Validation
[학술지(정기간행물)] - Andreia Freitas / 2014 / Multi-residue and multi-class method for the determination of antibiotics in bovine muscle by ultra-high-performance liquid chromatography tandem mass spectrometry / Meat Science 98 (1) : 58 ~ 64
[학술지(정기간행물)] - Héctor C. Goicoechea / 1999 / Enhanced Synchronous Spectrofluorometric Determination of Tetracycline in Blood Serum by Chemometric Analysis. Comparison of Partial Least-Squares and Hybrid Linear Analysis Calibrations / Analytical Chemistry 71 (19) : 4361 ~ 4368
[학술지(정기간행물)] - F.A. Guardiola / 2012 / Modulation of the immune parameters and expression of genes of gilthead seabream (Sparus aurata L.) by dietary administration of oxytetracycline / Aquaculture 334-337 : 51 ~ 57
[인터넷자원] - Food and drug administration / / Guidance for Industry Bioanalytical Method Validation
[학술지(정기간행물)] - Andreia Freitas / 2014 / Multi-residue and multi-class method for the determination of antibiotics in bovine muscle by ultra-high-performance liquid chromatography tandem mass spectrometry / Meat Science 98 (1) : 58 ~ 64
[학술지(정기간행물)] - Héctor C. Goicoechea / 1999 / Enhanced Synchronous Spectrofluorometric Determination of Tetracycline in Blood Serum by Chemometric Analysis. Comparison of Partial Least-Squares and Hybrid Linear Analysis Calibrations / Analytical Chemistry 71 (19) : 4361 ~ 4368
[학술지(정기간행물)] - F.A. Guardiola / 2012 / Modulation of the immune parameters and expression of genes of gilthead seabream (Sparus aurata L.) by dietary administration of oxytetracycline / Aquaculture 334-337 : 51 ~ 57
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UCI(KEPA) : I410-ECN-0101-2019-454-000146999