Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan

Yoenten Phuentshok; Kezang Dorji; Tandin Zangpo; Silas A. Davidson; Ratree Takhampunya; Tenzinla Tenzinla; Chencho Dorjee; Roger S. Morris; Peter D. Jolly; Sithar Dorjee; Joanna S. McKenzie

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저자정보: Yoenten Phuentshok (Massey University) Kezang Dorji (Massey University) Tandin Zangpo (Massey University) Silas A. Davidson (Armed Forces Research Institute of Medical Sciences (AFRIMS)) Ratree Takhampunya (Armed Forces Research Institute of Medical Sciences (AFRIMS)) Tenzinla Tenzinla (Ministry of Agriculture and Forests) Chencho Dorjee (Khesar Gyalpo University of Medical Sciences of Bhutan) Roger S. Morris (MorVet Ltd) Peter D. Jolly (Massey University) Sithar Dorjee (Khesar Gyalpo University of Medical Sciences of Bhutan) Joanna S. McKenzie (Massey University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.56 No.5

발행연도: 2018.10

수록면: 521 - 525 (5page)

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Rodents are well-known reservoirs and vectors of many emerging and re-emerging infectious diseases, but little is known about their role in zoonotic disease transmission in Bhutan. In this study, a cross-sectional investigation of zoonotic disease pathogens in rodents was performed in Chukha district, Bhutan, where a high incidence of scrub typhus and cases of acute undifferentiated febrile illness had been reported in people during the preceding 4-6 months. Twelve rodents were trapped alive using wire-mesh traps. Following euthanasia, liver and kidney tissues were removed and tested using PCR for Orientia tsutsugamushi and other bacterial and rickettsial pathogens causing bartonellosis, borreliosis, human monocytic ehrlichiosis, human granulocytic anaplasmosis, leptospirosis, and rickettsiosis. A phylogenetic analysis was performed on all rodent species captured and pathogens detected. Four out of the 12 rodents (33.3%) tested positive by PCR for zoonotic pathogens. Anaplasma phagocytophilum, Bartonella grahamii, and B. queenslandensis were identified for the first time in Bhutan. Leptospira interrogans was also detected for the first time from rodents in Bhutan. The findings demonstrate the presence of these zoonotic pathogens in rodents in Bhutan, which may pose a risk of disease transmission to humans.

#Leptospira #Anaplasma #Bartonella #emerging infectious disease #surveillance #rodent #zoonosis #Bhutan

참고문헌 (20)

참고문헌 신청

[보고서] - National Biodiversity Centre / 2014 / National Biodiversity Strategies and Action Plan of Bhutan : 191 ~

[보고서] - Department of Forests / 2017 / Ministry of Agriculture and Forests, Royal Government of Bhutan : 77 ~

[기타자료] - Wangchuk T / 2004 / A Field Guide to the Mammals of Bhutan / Ministry of Agriculture

[학술지(정기간행물)] - Luis AD / 2013 / A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? / Proc Biol Sci 280 : 20122753 ~

[학술지(정기간행물)] - Tshokey T / 2016 / Scrub typhus in Bhutan: a synthesis of data from 2009 to 2014 / WHO South East Asia J Public Health 5 : 117 ~ 122

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