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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 109 - 112 (4page)
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초록· 키워드
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Nowadays antibiotic resistance is a worldwide serious problem that mainly affects public health. Omadacycline is a unique antibiotic which has two available dosage forms such as intravenous (IV) and oral that development for community-acquired bacterial infectious disease treatment. It is a modified form of older tetracycline at C-9 aminomethyl substituent of 6-member core ring of tetracycline. Modification form shows its activity against efflux pump and ribosomal protein protection mechanism of tetracycline resistance. Generally, omadacycline is effective against methicillin-resistant S. aureus (MRSA), Streptococcus pneumoniae, vancomycinresistant Enterococcus (VRE), Legionella and Chlamydia spp. Efficacy, safety and tolerability profile of omadacycline those compares with recent antibiotics shows that omadacycline is less resistant than others. One derivative from tetracycline derivatives is 9-neopentylaminomethylminocycline called omadacycline was discovered and ongoing phase III clinical experiments as a therapy for acute bacterial skin and skin structure infections (ABSSSI) as well as community-acquired bacterial pneumonia (CABP). Omadacycline seems to be a strong drug candidate for future promising new antibacterial agent that is effective against ABSSSI and CABP.
목차
INTRODUCTION
DISCOVERY AND STRUCTURE ACTIVITY RELATIONSHIP OF OMADACYCLINE
MECHANISM OF ACTION OF OMADACYCLINE
WAY TO OVERCOME THE TETRACYCLINE RESISTANCE
IN VITRO AND IN VIVO STUDIES OF OMADACYCLINE
TRANSPORTER EFFECTS OF OMADACYCLINE
CLINICAL PROFILE AND EFFICACY OF OMADACYCLINE
CLOSING REMARKS
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2018-475-003564129