지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Breast cancer is one of the most common cancers affecting women worldwide. Although the survival rate of breast cancer has increased, breast cancer still results in a high mortality rate. Breast cancer deaths are caused by metastasis that occurs in organ dysfunction. Recently, there have been many studies on circulating tumor cells (CTCs), which are related to breast cancer metastasis in the blood. Recent studies have demonstrated that some CTCs do not express epithelial markers. Therefore, in this study, total RNA was extracted from blood without separating out the CTCs, and the characteristics of the CTCs were analyzed by RT-qPCR. Cyclin D1 and twist-related protein 1 (TWIST1) are well-known markers for predicting the prognosis of patients with breast cancer. However, few studies have demonstrated the use of CCND1 and TWIST1 in blood as diagnostic and prognostic markers of breast cancer. In this study, patients with late-stage breast cancer had overexpressed CCND1 and TWIST1 than patients with different stages of breast cancer (P < 0.001 and P < 0.01, respectively). The relative expression level of CCND1 in survivors was higher than in patients who died (P = 0.06). The relative expression level of TWIST1 in survivors was lower than in patients who died (P = 0.08). Overall CCND1 and TWIST1 were not useful as markers for the diagnosis of breast cancer through blood. However, we showed the possibility of using CCND1 and TWIST1 as prognostic markers, and a large-scale study is needed to confirm the usefulness of these prognostic markers.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - Ansieau S / 2010 / TWISTing an embryonic transcription factor into an oncoprotein / Oncogene 29 : 3173 ~ 3184
[학술지(정기간행물)] - Barnes DM / 1998 / Cyclin D1 in breast cancer / Breast Cancer Research and Treatment 52 : 1 ~ 15
[학술지(정기간행물)] - Barriere G / 2012 / Mesenchymal and stemness circulating tumor cells in early breast cancer diagnosis / BMC Cancer 12 : 114 ~ 120
[학술지(정기간행물)] - Bonnomet A / 2010 / Epithelial-to-mesenchymal transitions and circulating tumor cells / Journal of Mammary Gland Biology and Neoplasia 15 : 261 ~ 273
[학술지(정기간행물)] - Bostner J / 2007 / Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer / Oncogene 26 : 6997 ~ 7005
[학술지(정기간행물)] - Barnes DM / 1998 / Cyclin D1 in breast cancer / Breast Cancer Research and Treatment 52 : 1 ~ 15
[학술지(정기간행물)] - Barriere G / 2012 / Mesenchymal and stemness circulating tumor cells in early breast cancer diagnosis / BMC Cancer 12 : 114 ~ 120
[학술지(정기간행물)] - Bonnomet A / 2010 / Epithelial-to-mesenchymal transitions and circulating tumor cells / Journal of Mammary Gland Biology and Neoplasia 15 : 261 ~ 273
[학술지(정기간행물)] - Bostner J / 2007 / Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer / Oncogene 26 : 6997 ~ 7005
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