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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 550 - 558 (9page)
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초록· 키워드
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The purpose of current study is to investigate the beneficial effect of enzyme (Alcalase) hydrolysates of silk protein in rat. Alcalase-treated silk protein hydrolysate (ATSH) itself did not show any cytotoxicity on the hepatic tissues and blood biochemistry, similar to the normal condition. ATSH played a protective role in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity and liver damage. The values of AST (aspartate aminotransferase) and ALT (alanine aminotransferase), which are the indicators of the liver function, were effectively alleviated with the ATSH treatment in a dose dependent manner. The level of Lactate dehydrogenase (LDH) and Malondialdehyde (MDA), which were increased with t-BHP treatment, were significantly reduced by ATSH. High dose of ATSH (2 g/kg) reduced the t-BHP-induced LDH release by 48%. Antioxidant and antioxidant enzymes in liver cells were significantly increased by ATSH treatment in their level and activities. ATSH (2 g/kg) increased glutathione (GSH), an intracelluar antioxidant, by 2.5-fold compared with the t-BHP treated group. The activities of glutathione-s-transferase (GST), superoxide dismutase (SOD), and catalase were also elevated by 38%, 60%, and 45%, respectively, with ATSH (2 g/kg) treatment. The antioxidative effect of ATSH was recapitulated to the protection from t-BHP induced liver damages in hematoxylin and eosin (H&E) staining. Thus, ATSH might be used as a hepatoprotective agent.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (37)
참고문헌 신청
[학술지(정기간행물)] - Kim J / 2014 / Silk peptide treatment can improve the exercise performance of mice / J Int Soc Sports Nutr 11 : 35 ~
[학술지(정기간행물)] - Lee SH / 2002 / Physiologic functionality of silk peptides-focus on antioxidant and immune function / Food Science and Industry 35 : 57 ~ 61
[학술지(정기간행물)] - Hwang E / 2001 / Protein quality evaluation and effect of plasma lipid contents of acid hydrolysates of cocoon in rats fed by high cholesterol, high triglyceride and high sucrose diet / J Korean Soc Food Sci Nutr 30 : 1004 ~ 1009
[학술지(정기간행물)] - Zhaorigetu S / 2003 / Inhibitory effects of silk protein, sericin on UVB-induced acute damage and tumor promotion by reducing oxidative stress in the skin of hairless mouse / J Photochem Photobiol B 71 : 11 ~ 17
[학술지(정기간행물)] - 김애정 / 2005 / 뽕잎분말이 고콜레스테롤 식이 투여 흰쥐의 지질대사에 미친 영향 / 한국식품과학회지 37 (4) : 636 ~ 641
[학술지(정기간행물)] - Lee SH / 2002 / Physiologic functionality of silk peptides-focus on antioxidant and immune function / Food Science and Industry 35 : 57 ~ 61
[학술지(정기간행물)] - Hwang E / 2001 / Protein quality evaluation and effect of plasma lipid contents of acid hydrolysates of cocoon in rats fed by high cholesterol, high triglyceride and high sucrose diet / J Korean Soc Food Sci Nutr 30 : 1004 ~ 1009
[학술지(정기간행물)] - Zhaorigetu S / 2003 / Inhibitory effects of silk protein, sericin on UVB-induced acute damage and tumor promotion by reducing oxidative stress in the skin of hairless mouse / J Photochem Photobiol B 71 : 11 ~ 17
[학술지(정기간행물)] - 김애정 / 2005 / 뽕잎분말이 고콜레스테롤 식이 투여 흰쥐의 지질대사에 미친 영향 / 한국식품과학회지 37 (4) : 636 ~ 641
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UCI(KEPA) : I410-ECN-0101-2018-059-001945377