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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 24 - 42 (19page)
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초록· 키워드
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Tuberculosis (TB) is a contagious disease that has been responsible for the death of one billion people in the last 200 years. Until now, the only vaccine approved for the prevention of TB is Bacillus Calmette-Guérin (BCG), which is prepared by attenuating Mycobacterium bovis. However, one of the limitations of BCG is that its preventive effect against pulmonary TB varies from person to person. Therefore, there arises a need for a new TB vaccine to replace or supplement BCG. In this review, we have summarized the findings of current clinical trials on preventive and therapeutic TB vaccine candidates. In addition, we have discussed a novel vaccination approach using the cell-based vaccine presenting early secretory antigenic target-6 (ESAT-6), which is a potent immunogenic antigen. The role of ESAT-6 in hosts has also been described.
목차
ABSTRACT
INTRODUCTION
EPIDEMIOLOGY
DEVELOPMENT OF NEW PREVENTIVE TB VACCINES
DEVELOPMENT OF NEW THERAPEUTIC TB VACCINES
NEW APPROACHES FOR TB VACCINE DEVELOPMENT
ADVANTAGES AND DISADVANTAGES OF ESAT-6 AS A VACCINE ANTIGEN
CONCLUSION
REFERENCES
참고문헌 (85)
참고문헌 신청
Paulson T / 2013 / Epidemiology: a mortal foe / Nature 502:S2~S3
World Health Organization / 2016 / Global Tuberculosis Report 2016
Havlir DV / 2008 / Opportunities and challenges for HIV care in overlapping HIV and TB epidemics / JAMA 300:423~430
Lonnroth K / 2010 / Tuberculosis control and elimination 2010-50: cure, care, and social development / Lancet 375:1814~1829
Rehm J / 2009 / The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review / BMC Public Health 9:450
World Health Organization / 2016 / Global Tuberculosis Report 2016
Havlir DV / 2008 / Opportunities and challenges for HIV care in overlapping HIV and TB epidemics / JAMA 300:423~430
Lonnroth K / 2010 / Tuberculosis control and elimination 2010-50: cure, care, and social development / Lancet 375:1814~1829
Rehm J / 2009 / The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review / BMC Public Health 9:450
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UCI(KEPA) : I410-ECN-0101-2018-517-002013062