지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 75 - 81 (7page)
이용수
초록· 키워드
오류제보하기
Background: Exposure to sustained high concentrations of HCFC-123 is known to be hepatotoxic. We report two simultaneous cases of toxic hepatitis related to exposure to 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123), a common refrigerant, at a Korean fire extinguisher manufacturing facility.
Case presentation: Patients A and B were men aged 21 and 22 years, respectively, with no notable medical histories. They had recently started working for a manufacturer of fire extinguishers. During the third week of their employment, they visited the emergency center of a general hospital due to fever, lack of appetite, and general weakness. At the time of their visit, they were suspected as having hepatitis due to elevated aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and total bilirubin levels and were hospitalized. However, as their condition did not improve, they were moved to a tertiary general hospital. After conservative treatment, one patient improved but the other died from acute hepatic failure. Assessments of the work environment showed that the short-term exposure levels of HCFC-123 for valve assembly processes were as high as 193.4 ppm. A transjugular liver biopsy was performed in patient A; the results indicated drug/toxin-induced liver injury (DILI). Given the lack of a medical history and the occupational exposure to high levels of HCFC-123, a hepatotoxic agent, the toxic hepatitis of the workers was likely related to HCFC-123 exposure.
Conclusions: Work environment assessments have not included this agent. To the best of our knowledge, we are the first to report a case of death related to HCFC-123-induced liver damage. Our findings suggest that exposure standards and limits for HCFC-123 must be developed in Korea; work environments will have to be improved based on such standards.
Case presentation: Patients A and B were men aged 21 and 22 years, respectively, with no notable medical histories. They had recently started working for a manufacturer of fire extinguishers. During the third week of their employment, they visited the emergency center of a general hospital due to fever, lack of appetite, and general weakness. At the time of their visit, they were suspected as having hepatitis due to elevated aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and total bilirubin levels and were hospitalized. However, as their condition did not improve, they were moved to a tertiary general hospital. After conservative treatment, one patient improved but the other died from acute hepatic failure. Assessments of the work environment showed that the short-term exposure levels of HCFC-123 for valve assembly processes were as high as 193.4 ppm. A transjugular liver biopsy was performed in patient A; the results indicated drug/toxin-induced liver injury (DILI). Given the lack of a medical history and the occupational exposure to high levels of HCFC-123, a hepatotoxic agent, the toxic hepatitis of the workers was likely related to HCFC-123 exposure.
Conclusions: Work environment assessments have not included this agent. To the best of our knowledge, we are the first to report a case of death related to HCFC-123-induced liver damage. Our findings suggest that exposure standards and limits for HCFC-123 must be developed in Korea; work environments will have to be improved based on such standards.
목차
Abstract
Background
Case presentation
Discussion and conclusions
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
소화기공장 노동자에서 2,2-Dichloro-1,1,1-Trifluoroethane(HCFC-123) 노출로 인해 발생한 독성 간염 1예
대한직업환경의학회 학술대회 논문집
2017 .11
-
HCFC-123의 급성 독성간질환 발생 사례에 따른 노출기준 및 법 관리 필요성 권고
한국산업보건학회지
2018 .01
-
HCFC-123 화재용 소화약제에 의한 독성간염
대한직업환경의학회 학술대회 논문집
2017 .11
-
A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
대한직업환경의학회지
2022 .09
-
간기능의 올바른 해석
대한내과학회지
2019 .02
-
만성 활동성 B형 간염 질환 환자의 요추간판 탈출증 치험례
대한한방내과학회지
2016 .01
-
Does drug-induced liver injury still occur after sevoflurane anesthesia? -A case report-
Anesthesia and Pain Medicine
2024 .07
-
De novo hepatitis B virus infection after liver transplantation in hepatitis B core-positive recipients using hepatitis B core-negative grafts
한국간담췌외과학회 학술대회지
2015 .09
-
Current and future strategies for the treatment of chronic hepatitis C
Clinical and Molecular Hepatology
2021 .01
-
약인성 간손상 환자에 대한 生肝湯 치험 1례
대한한방내과학회지
2019 .01
-
한약복용이 한방병원 입원환자의 간 기능에 미치는 영향에 대한 후향적 관찰
대한한방내과학회지
2019 .01
-
Acute hepatitis A, B and C but not D is still prevalent in Mongolia: a time trend analysis
Clinical and Molecular Hepatology
2017 .06
-
노출평가 방법론에 대한 과거와 현재, 그리고 미래
한국환경보건학회지
2022 .06
-
Acute Viral Hepatitis A with Cholestatic Hepatitis Treated with Traditional Korean Medicine : A Case Report
대한한의학회지
2015 .12
-
Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure
Clinical and Molecular Hepatology
2015 .01
-
국내외 소비자 제품 노출평가모델을 이용한 노출량 비교
한국환경보건학회지
2024 .02
-
Association Between Cadmium Exposure and Liver Function in Adults in the United States: A Cross-sectional Study
예방의학회지
2021 .11
-
A challenge in distinguishing between acute hepatitis B and acute exacerbation of chronic hepatitis B
Clinical and Molecular Hepatology
2020 .01
-
Reuse of liver allograft from a brain-dead recipient: A case report
Annals of Hepato-Biliary-Pancreatic Surgery
2020 .05
-
Evaluation of the histological scoring systems of autoimmune hepatitis: A significant step towards the optimization of clinical diagnosis
Clinical and Molecular Hepatology
2024 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0