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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.94 No.3
- 발행연도
- 2018.3
- 수록면
- 118 - 128 (11page)
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Purpose: Posthepatectomy liver failure is a serious complication and considered to be caused by increased portal pressure and flow. Splanchnic vasoactive agents and propranolol are known to decrease portal pressure. The aim of this study was to identify optimal candidates with potential for clinical use among somatostatin, terlipressin, and propranolol using rats with 90% hepatectomy.
Methods: Rats were divided into 5 groups: sham operation (n = 6), control (n = 20), propranolol (n = 20), somatostatin (n = 20), and terlipressin group (n = 20). Seven-day survival rates and portal pressure change were measured, and biochemical, histologic, and molecular analyses were performed.
Results: Portal pressure was significantly decreased in all 3 treatment groups compared to control. All treatment groups showed a tendency of decreased liver injury markers, and somatostatin showed the most prominent effect at 24 hours postoperatively. Histologic liver injury at 24 hours was significantly decreased in propranolol and terlipressin groups (P = 0.016, respectively) and somatostatin group showed borderline significance (P = 0.056). Hepatocyte proliferation was significantly increased after 24 hours in all treatment groups. Median survival was significantly increased in terlipressin group compared to control group (P < 0.01).
Conclusion: Terlipressin is considered as the best candidate, while somatostatin has good potential for clinical use, considering their effects on portal pressure and subsequent decrease in liver injury and increase in liver regeneration.
Methods: Rats were divided into 5 groups: sham operation (n = 6), control (n = 20), propranolol (n = 20), somatostatin (n = 20), and terlipressin group (n = 20). Seven-day survival rates and portal pressure change were measured, and biochemical, histologic, and molecular analyses were performed.
Results: Portal pressure was significantly decreased in all 3 treatment groups compared to control. All treatment groups showed a tendency of decreased liver injury markers, and somatostatin showed the most prominent effect at 24 hours postoperatively. Histologic liver injury at 24 hours was significantly decreased in propranolol and terlipressin groups (P = 0.016, respectively) and somatostatin group showed borderline significance (P = 0.056). Hepatocyte proliferation was significantly increased after 24 hours in all treatment groups. Median survival was significantly increased in terlipressin group compared to control group (P < 0.01).
Conclusion: Terlipressin is considered as the best candidate, while somatostatin has good potential for clinical use, considering their effects on portal pressure and subsequent decrease in liver injury and increase in liver regeneration.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Helling TS / 2006 / Liver failure following partial hepatectomy / HPB (Oxford) 8 : 165 ~ 174
[학술지(정기간행물)] - Dahm F / 2005 / Smallfor-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications / Am J Transplant 5 : 2605 ~ 2610
[학술지(정기간행물)] - Rahbari NN / 2011 / Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS) / Surgery 149 : 713 ~ 724
[학술지(정기간행물)] - Golriz M / 2016 / Small for Size and Flow (SFSF) syndrome: an alternative description for posthepatectomy liver failure / Clin Res Hepatol Gastroenterol 40 : 267 ~ 275
[학술지(정기간행물)] - Panis Y / 1997 / Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection / Surgery 121 : 142 ~ 149
[학술지(정기간행물)] - Dahm F / 2005 / Smallfor-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications / Am J Transplant 5 : 2605 ~ 2610
[학술지(정기간행물)] - Rahbari NN / 2011 / Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS) / Surgery 149 : 713 ~ 724
[학술지(정기간행물)] - Golriz M / 2016 / Small for Size and Flow (SFSF) syndrome: an alternative description for posthepatectomy liver failure / Clin Res Hepatol Gastroenterol 40 : 267 ~ 275
[학술지(정기간행물)] - Panis Y / 1997 / Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection / Surgery 121 : 142 ~ 149
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UCI(KEPA) : I410-ECN-0101-2018-514-001804868