지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 89 - 96 (8page)
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초록· 키워드
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The protective effect of ginsenoside Re, isolated from ginseng berry, against acute gastric mucosal lesions was examined in rats with a single intraperitoneal injection of compound 48/80 (C48/80). Ginsenoside Re (20 mg/kg or 100 mg/kg) was orally administered 0.5 h prior to C48/80 treatment. Ginsenoside Re dose-dependently prevented gastric mucosal lesion development 3 h after C48/80 treatment. Increases in the activities of myeloperoxidase (MPO; an index of neutrophil infiltration) and xanthine oxidase (XO) and the content of thiobarbituric acid reactive substances (TBARS; an index of lipid peroxidation) and decreases in the contents of hexosamine (a marker of gastric mucus) and adherent mucus, which occurred in gastric mucosal tissues after C48/80 treatment, were significantly attenuated by ginsenoside Re. The elevation of Bax expression and the decrease in Bcl2 expression after C48/80 treatment were also attenuated by ginsenoside Re. Ginsenoside Re significantly attenuated all these changes 3 h after C48/80 treatment. These results indicate that orally administered ginsenoside Re protects against C48/80- induced acute gastric mucosal lesions in rats, possibly through its stimulatory action on gastric mucus synthesis and secretion, its inhibitory action on neutrophil infiltration, and enhanced lipid peroxidation in the gastric mucosal tissue.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Shibata S / 1966 / Chemical studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins / Chem Pharm Bull 14 : 595 ~ 600
2. [학술지(정기간행물)] - Kim YK / 2009 / Ginsenoside content of berries and roots of three typical Korean ginseng (Panax ginseng) cultivars / Nat Prod Commun 4 : 903 ~ 906
3. [학술지(정기간행물)] - Attele AS / 2002 / Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component / Diabetes 51 : 1851 ~ 1858
4. [학술지(정기간행물)] - Xie JT / 2005 / Anti-diabetic effect of ginsenoside Re in ob/ob mice / Biochim Biophys Acta 1740 : 319 ~ 325
5. [학술지(정기간행물)] - Yang CY / 2010 / Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components / J Ethnopharmacol 130 : 231 ~ 236
2. [학술지(정기간행물)] - Kim YK / 2009 / Ginsenoside content of berries and roots of three typical Korean ginseng (Panax ginseng) cultivars / Nat Prod Commun 4 : 903 ~ 906
3. [학술지(정기간행물)] - Attele AS / 2002 / Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component / Diabetes 51 : 1851 ~ 1858
4. [학술지(정기간행물)] - Xie JT / 2005 / Anti-diabetic effect of ginsenoside Re in ob/ob mice / Biochim Biophys Acta 1740 : 319 ~ 325
5. [학술지(정기간행물)] - Yang CY / 2010 / Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components / J Ethnopharmacol 130 : 231 ~ 236
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UCI(KEPA) : I410-ECN-0101-2018-524-001597191