지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.7
- 수록면
- 173 - 179 (7page)
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초록· 키워드
오류제보하기
Background: Ginsenosides are the major components responsible for the biochemical and pharmacological actions of ginseng, and have been shown to have various biological activities. In this study, we investigated the antiviral activities of seven ginsenosides [protopanaxatriol (PT) type: Re, Rf, and Rg2; protopanaxadiol (PD) type: Rb1, Rb2, Rc, and Rd)] against coxsackievirus B3 (CVB3), enterovirus 71 (EV71), and human rhinovirus 3 (HRV3).
Methods: Assays of antiviral activity and cytotoxicity were evaluated by the sulforhodamine B method using the cytopathic effect (CPE) reduction assay.
Results: The antiviral assays demonstrated that, of the seven ginsenosides, the PT-type ginsenosides (Re, Rf, and Rg2) possess significant antiviral activities against CVB3 and HRV3 at a concentration of 100 μg/mL. Among the PT-type ginsenosides, only ginsenoside Rg2 showed significant anti-EV71 activity with no cytotoxicity to cells at 100 μg/mL. The PD-type ginsenosides (Rb1, Rb2, Rc, and Rd), by contrast, did not show any significant antiviral activity against CVB3, EV71, and HRV3, and exhibited cytotoxic effects to virus-infected cells. Notably, the antiviral efficacies of PT-type ginsenosides were comparable to those of ribavirin, a commonly used antiviral drug.
Conclusion: Collectively, our findings suggest that the ginsenosides Re, Rf, and Rg2 have the potential to be effective in the treatment of CVB3, EV71, and HRV3 infection.
Methods: Assays of antiviral activity and cytotoxicity were evaluated by the sulforhodamine B method using the cytopathic effect (CPE) reduction assay.
Results: The antiviral assays demonstrated that, of the seven ginsenosides, the PT-type ginsenosides (Re, Rf, and Rg2) possess significant antiviral activities against CVB3 and HRV3 at a concentration of 100 μg/mL. Among the PT-type ginsenosides, only ginsenoside Rg2 showed significant anti-EV71 activity with no cytotoxicity to cells at 100 μg/mL. The PD-type ginsenosides (Rb1, Rb2, Rc, and Rd), by contrast, did not show any significant antiviral activity against CVB3, EV71, and HRV3, and exhibited cytotoxic effects to virus-infected cells. Notably, the antiviral efficacies of PT-type ginsenosides were comparable to those of ribavirin, a commonly used antiviral drug.
Conclusion: Collectively, our findings suggest that the ginsenosides Re, Rf, and Rg2 have the potential to be effective in the treatment of CVB3, EV71, and HRV3 infection.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (41)
참고문헌 신청
1. [학술지(정기간행물)] - Whitton JL / 2005 / Host and virus determinants of picornavirus pathogenesis and tropism / Nat Rev Microbiol 3 : 765 ~ 776
2. [학술지(정기간행물)] - Chumakov M / 1979 / Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria / Arch Virol 60 : 329 ~ 340
3. [학술지(정기간행물)] - McMinn PC / 2002 / An overview of the evolution of enterovirus 71 and its clinical and public health significance / FEMS Microbiol Rev 6 : 91 ~ 107
4. [학술지(정기간행물)] - Wang SM / 2003 / Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema / J Infect Dis 188 : 564 ~ 570
5. [학술지(정기간행물)] - 송재형 / 2014 / Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a / Biomolecules & Therapeutics 22 (1) : 41 ~ 46
2. [학술지(정기간행물)] - Chumakov M / 1979 / Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria / Arch Virol 60 : 329 ~ 340
3. [학술지(정기간행물)] - McMinn PC / 2002 / An overview of the evolution of enterovirus 71 and its clinical and public health significance / FEMS Microbiol Rev 6 : 91 ~ 107
4. [학술지(정기간행물)] - Wang SM / 2003 / Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema / J Infect Dis 188 : 564 ~ 570
5. [학술지(정기간행물)] - 송재형 / 2014 / Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a / Biomolecules & Therapeutics 22 (1) : 41 ~ 46
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UCI(KEPA) : I410-ECN-0101-2018-524-001597308