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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 105 - 115 (11page)
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초록· 키워드
오류제보하기
Background: Alcoholic steatosis is the earliest and most common liver disease, and may precede the onset of more severe forms of liver injury.
Methods: The effect of Korean Red Ginseng extract (RGE) was tested in two murine models of ethanol (EtOH)-feeding and EtOH-treated hepatocytes.
Results: Blood biochemistry analysis demonstrated that RGE treatment improved liver function. Histopathology and measurement of hepatic triglyceride content verified the ability of RGE to inhibit fat accumulation. Consistent with this, RGE administration downregulated hepatic lipogenic gene induction and restored hepatic lipolytic gene repression by EtOH. The role of oxidative stress in the pathogenesis of alcoholic liver diseases is well established. Treatment with RGE attenuated EtOH-induced cytochrome P450 2E1, 4-hydroxynonenal, and nitrotyrosine levels. Alcohol consumption also decreased phosphorylation of adenosine monophosphate-activated protein kinase, which was restored by RGE. Moreover, RGE markedly inhibited fat accumulation in EtOH-treated hepatocytes, which correlated with a decrease in sterol regulatory element-binding protein-1 and a commensurate increase in sirtuin 1 and peroxisome proliferator-activated receptor-α expression. Interestingly, the ginsenosides Rb2 and Rd, but not Rb1, significantly inhibited fat accumulation in hepatocytes.
Conclusion: These results demonstrate that RGE and its ginsenoside components inhibit alcoholic steatosis and liver injury by adenosine monophosphate-activated protein kinase/sirtuin 1 activation both in vivo and in vitro, suggesting that RGE may have a potential to treat alcoholic liver disease.
Methods: The effect of Korean Red Ginseng extract (RGE) was tested in two murine models of ethanol (EtOH)-feeding and EtOH-treated hepatocytes.
Results: Blood biochemistry analysis demonstrated that RGE treatment improved liver function. Histopathology and measurement of hepatic triglyceride content verified the ability of RGE to inhibit fat accumulation. Consistent with this, RGE administration downregulated hepatic lipogenic gene induction and restored hepatic lipolytic gene repression by EtOH. The role of oxidative stress in the pathogenesis of alcoholic liver diseases is well established. Treatment with RGE attenuated EtOH-induced cytochrome P450 2E1, 4-hydroxynonenal, and nitrotyrosine levels. Alcohol consumption also decreased phosphorylation of adenosine monophosphate-activated protein kinase, which was restored by RGE. Moreover, RGE markedly inhibited fat accumulation in EtOH-treated hepatocytes, which correlated with a decrease in sterol regulatory element-binding protein-1 and a commensurate increase in sirtuin 1 and peroxisome proliferator-activated receptor-α expression. Interestingly, the ginsenosides Rb2 and Rd, but not Rb1, significantly inhibited fat accumulation in hepatocytes.
Conclusion: These results demonstrate that RGE and its ginsenoside components inhibit alcoholic steatosis and liver injury by adenosine monophosphate-activated protein kinase/sirtuin 1 activation both in vivo and in vitro, suggesting that RGE may have a potential to treat alcoholic liver disease.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - Frazier TH / 2011 / Treatment of alcoholic liver disease / Therap Adv Gastroenterol 4 : 63 ~ 81
2. [학술지(정기간행물)] - Gramenzi A / 2006 / Review article: alcoholic liver diseasedpathophysiological aspects and risk factors / Aliment Pharmacol Ther 24 : 1151 ~ 1161
3. [학술지(정기간행물)] - Dey A / 2006 / Alcohol and oxidative liver injury / Hepatology 43 : S63 ~ S74
4. [학술지(정기간행물)] - Lu Y / 2008 / CYP2E1 and oxidative liver injury by alcohol / Free Radic Biol Med 44 : 723 ~ 738
5. [학술지(정기간행물)] - Morgan K / 2002 / Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage / Hepatology 36 : 122 ~ 134
2. [학술지(정기간행물)] - Gramenzi A / 2006 / Review article: alcoholic liver diseasedpathophysiological aspects and risk factors / Aliment Pharmacol Ther 24 : 1151 ~ 1161
3. [학술지(정기간행물)] - Dey A / 2006 / Alcohol and oxidative liver injury / Hepatology 43 : S63 ~ S74
4. [학술지(정기간행물)] - Lu Y / 2008 / CYP2E1 and oxidative liver injury by alcohol / Free Radic Biol Med 44 : 723 ~ 738
5. [학술지(정기간행물)] - Morgan K / 2002 / Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage / Hepatology 36 : 122 ~ 134
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UCI(KEPA) : I410-ECN-0101-2018-524-001597631