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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 299 - 303 (5page)
이용수
초록· 키워드
오류제보하기
Panax ginseng is a well-known economic medical plant that is widely used in Chinese traditional medicine. This species contains a unique class of natural productsdginsenosides. Recent clinical and experimental studies have presented numerous lines of evidence on the promising role of ginsenosides on different diseases including neurodegenerative diseases, cardiovascular diseases, and certain types of cancer. Nowadays, most of the attention has focused on ginsenoside Rd as a neuroprotective agent to attenuate ischemic stroke damages. Some of the evidence showed that ginsenoside Rd ameliorates ischemic stroke-induced damages through the suppression of oxidative stress and inflammation. Ginsenoside Rd can prolong neural cells’ survival through the upregulation of the endogenous antioxidant system, phosphoinositide-3-kinase/AKT and extracellular signal-regulated protein kinase 1/2 pathways, preservation of mitochondrial membrane potential, suppression of the nuclear factor-kappa B, transient receptor potential melastatin, acid sensing ion channels 1a, poly(ADP-ribose) polymerase-1, protein tyrosine kinase activation, as well as reduction of cytochrome c-releasing and apoptosis-inducing factor. In the current work, we review the available reports on the promising role of ginsenoside Rd on ischemic stroke. We also discuss its chemistry, source, and the molecular mechanism underlying this effect.
목차
abstract
1. Introduction
2. Source and chemistry
3. Ginsenoside Rd and ischemic stroke
4. Conclusion and recommendation
References
참고문헌 (98)
참고문헌 신청
[학술지(정기간행물)] - Mukherjee D / 2011 / Epidemiology and the global burden of stroke / World Neurosurg 76 : S85 ~ S90
[학술지(정기간행물)] - Grysiewicz RA / 2008 / Epidemiology of ischemic and hemorrhagic stroke: incidence, prevalence, mortality, and risk factors / Neurol Clin 26 : 871 ~ 895
[학술지(정기간행물)] - Kleinig TJ / 2009 / Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options / Curr Opin Neurol 22 : 294 ~ 301
[학술지(정기간행물)] - Nabavi SF / 2014 / Resveratrol and stroke: from chemistry to medicine / Curr Neurovasc Res 11 : 390 ~ 397
[학술지(정기간행물)] - Hossmann K-A / 2012 / The two pathophysiologies of focal brain ischemia: implications for translational stroke research / J Cereb Blood Flow Metab 32 : 1310 ~ 1316
[학술지(정기간행물)] - Grysiewicz RA / 2008 / Epidemiology of ischemic and hemorrhagic stroke: incidence, prevalence, mortality, and risk factors / Neurol Clin 26 : 871 ~ 895
[학술지(정기간행물)] - Kleinig TJ / 2009 / Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options / Curr Opin Neurol 22 : 294 ~ 301
[학술지(정기간행물)] - Nabavi SF / 2014 / Resveratrol and stroke: from chemistry to medicine / Curr Neurovasc Res 11 : 390 ~ 397
[학술지(정기간행물)] - Hossmann K-A / 2012 / The two pathophysiologies of focal brain ischemia: implications for translational stroke research / J Cereb Blood Flow Metab 32 : 1310 ~ 1316
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UCI(KEPA) : I410-ECN-0101-2018-524-001597873