지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 328 - 333 (6page)
- DOI
- 10.15188/kjopp.2017.12.31.6.328
이용수
초록· 키워드
오류제보하기
Desomodii Herba (DH) has been shown to exhibit pharmacologyical activities, such as increase myocaridal contraction and secretion of hepatic bile. DH is used to reduce pain caused by rheumatoid arthritis(RA) in Korean medicine. However, the DH exact(DHE) effect and mechanism on rheumatoid arthritis are unknown. In this study, we aimed at the inhibitory effect of DHE on rheumatoid arthritis, and investigated the effect in collagen-induced mice arthritis model and TNF-αinduced MMP-1 and MMP-3 expression including the molecular basis in rheumatoid arthritis synovial fibroblasts (RASFs).The effect of DHE on RA was measured by clinical scoring system. In RASFs, expression of MMP-1 and MMP-3 was assessed by Western blotting and real-time PCR. Also, Western blotting used to evaluate the phosphorylation levels of p38, ERK and JNK and activation of NF-κB and AP-1. Our results showed that DHE reduced collagen-induced arthritis in mice. DHE inhibits TNF-αinduced MMP-1 and MMP-3 expression and mRNA levels in RASFs. The inhibitory effect of DHE was mediated by the inhibition of the AP-1/JNK signaling pathway. Taken together, our results suggest that the DHE may have preventive potential for rheumatoid arthritis.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Pap T / 2000 / Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis / Arthritis Res 2 : 361 ~ 367
[학술지(정기간행물)] - Yoshihara Y / 2000 / Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis / Ann Rheum Dis 59 : 455 ~ 464
[학술지(정기간행물)] - Aviña-Zubieta JA / 2008 / Risk of cardiovascular mortality in patients with rheumatoid arthritis : a meta-analysis of observational studies / Arthritis Rheum 59 : 1690 ~ 1697
[학술지(정기간행물)] - Crisp AJ / 1982 / Rheumatoid lung disease, pneumothorax, and eosinophilia / Ann Rheum Dis 41 : 137 ~ 140
[학술지(정기간행물)] - Joana FF / 2016 / Glucocorticoids and Rhematoid Arthritis / Rheum dis Clin North Am 42 : 33 ~ 46
[학술지(정기간행물)] - Yoshihara Y / 2000 / Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis / Ann Rheum Dis 59 : 455 ~ 464
[학술지(정기간행물)] - Aviña-Zubieta JA / 2008 / Risk of cardiovascular mortality in patients with rheumatoid arthritis : a meta-analysis of observational studies / Arthritis Rheum 59 : 1690 ~ 1697
[학술지(정기간행물)] - Crisp AJ / 1982 / Rheumatoid lung disease, pneumothorax, and eosinophilia / Ann Rheum Dis 41 : 137 ~ 140
[학술지(정기간행물)] - Joana FF / 2016 / Glucocorticoids and Rhematoid Arthritis / Rheum dis Clin North Am 42 : 33 ~ 46
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UCI(KEPA) : I410-ECN-0101-2018-519-001666716