The effect of Korean Red Ginseng extract on rosiglitazone-induced improvement of glucose regulation in diet-induced obese mice

Mi-Jeong Oh; Hyun-Ju Kim; Eun-Young Park; Na-Hee Ha; Mun-Gyu Song; Sang-Hyun Choi; Boe-Gwun Chun; Dong-Hoon Kim

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자료유형: 학술저널

저자정보: Mi-Jeong Oh (Korea University College of Medicine) Hyun-Ju Kim (Korea University College of Medicine) Eun-Young Park (Korea University College of Medicine) Na-Hee Ha (Korea University College of Medicine) Mun-Gyu Song (Korea University College of Medicine) Sang-Hyun Choi (Korea University College of Medicine) Boe-Gwun Chun (Korea University College of Medicine) Dong-Hoon Kim (Korea University College of Medicine)

저널정보: 고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.41 No.1

발행연도: 2017.1

수록면: 52 - 59 (8page)

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Background: Korean Red Ginseng extract (KRG, Panax ginseng Meyer) and its constituents have been used for treating diabetes. However, in diet-induced obese mice, it is unclear whether KRG can enhance the glucose-lowering action of rosiglitazone (ROSI), a peroxisome proliferator-activated receptor gamma synthetic activator.
Methods: Oral glucose tolerance tests (oGTTs) were performed after 4 days of treatment with a vehicle (CON), KRG [500 mg/kg body weight (b.w.)], ROSI (3.75 mg/kg b.w, 7.5 mg/kg b.w, and 15 mg/kg b.w.), or ROSI and KRG (RK) in obese mice on a high-fat diet. Adipose tissue morphology, crown-like structures (CLSs), and inflammation were compared by hematoxylin-eosin staining or quantitative reverse transcription polymerase chain reaction.
Results: The area under the glucose curve (AUC) was significantly lower in the RK group (15 mg/kg b.w. and 500 mg/kg b.w. for ROSI and KRG, respectively) than in the CON group. There was no significant difference in the AUC between the CON and the other groups. Furthermore, the AUC was significantly lower in the RK group than in the ROSI group. The expression of the Ccl2 gene and the number of CLSs were significantly reduced in the RK group than in the CON group.
Conclusion: Our results show a potential enhancement of ROSI-induced improvement of glucose regulation by the combined treatment with KRG.

#adipose tissue #glucose regulation #inflammation #Korean Red Ginseng #rosiglitazone

참고문헌 (29)

참고문헌 신청

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