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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.11
- 수록면
- 1 - 6 (6page)
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초록· 키워드
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Background: The aim of this review was to estimate the lethal and exposure doses of a representative symptom (blindness) of methanol exposure in humans by reviewing data from previous articles.
Methods: Available articles published from 1970 to 2016 that investigated the dose-response relationship for methanol exposure (i.e., the exposure concentration and the biological markers/clinical symptoms) were evaluated; the MEDLINE and RISS (Korean search engine) databases were searched. The available data from these articles were carefully selected to estimate the range and median of a lethal human dose. The regression equation and correlation coefficient (between the exposure level and urinary methanol concentration as a biological exposure marker) were assumed from the previous data.
Results: The lethal human dose of pure methanol was estimated at 15.8–474 g/person as a range and as 56. 2 g/person as the median. The dose-response relationship between methanol vapor in ambient air and urinary methanol concentrations was thought to be correlated. An oral intake of 3.16–11.85 g/person of pure methanol could cause blindness. The lethal dose from respiratory intake was reported to be 4000–13,000 mg/l. The initial concentration of optic neuritis and blindness were shown to be 228.5 and 1103 mg/l, respectively, for a 12-h exposure.
Conclusion: The concentration of biological exposure indices and clinical symptoms for methanol exposure might have a dose-response relationship according to previous articles. Even a low dose of pure methanol through oral or respiratory exposure might be lethal or result in blindness as a clinical symptom.
Methods: Available articles published from 1970 to 2016 that investigated the dose-response relationship for methanol exposure (i.e., the exposure concentration and the biological markers/clinical symptoms) were evaluated; the MEDLINE and RISS (Korean search engine) databases were searched. The available data from these articles were carefully selected to estimate the range and median of a lethal human dose. The regression equation and correlation coefficient (between the exposure level and urinary methanol concentration as a biological exposure marker) were assumed from the previous data.
Results: The lethal human dose of pure methanol was estimated at 15.8–474 g/person as a range and as 56. 2 g/person as the median. The dose-response relationship between methanol vapor in ambient air and urinary methanol concentrations was thought to be correlated. An oral intake of 3.16–11.85 g/person of pure methanol could cause blindness. The lethal dose from respiratory intake was reported to be 4000–13,000 mg/l. The initial concentration of optic neuritis and blindness were shown to be 228.5 and 1103 mg/l, respectively, for a 12-h exposure.
Conclusion: The concentration of biological exposure indices and clinical symptoms for methanol exposure might have a dose-response relationship according to previous articles. Even a low dose of pure methanol through oral or respiratory exposure might be lethal or result in blindness as a clinical symptom.
목차
Abstract
Background
Methods
Results and discussion
Conclusion
References
참고문헌 (38)
참고문헌 신청
IPCS. Environmental Health Criteria 196. Methanol. WHO Geneva, 1997. IPCS INCHAEM Home; http://www.inchem.org/documents/ehc/ehc/ehc196.htm.
Becalski A, Bartlett KH. Methanol exposure to car occupants from windshileld washing fluid: a pilot study. Indoor Air. 2006;16(2):153?7.
Korea Occupational Safety & Health Agency (KOSHA). Standard of biological exposure indices and analytical methods I-16 Organic solvents (etc. Xylene) (Health division-Research Material-Institute 2010-64-880) KOSHA. 2010.
Kalkan S, Cevik AA, Cavdar C, Aygoren O, Akgun A, Ergun N, et al. Acute methanol poisonings reported to the drug and poison information Center in Izmir. Turkey Vet Hum Toxicol. 2003;45(6):334?7.
van Kampen RJ, Krekels MM, Derijks HJ, Peters FP. Serious intoxication after inhaling methanol. Ned Tijdschr Geneeskd. 2006;150(23):1298?302.
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UCI(KEPA) : I410-ECN-0101-2018-517-001566893