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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 169 - 173 (5page)
- DOI
- 10.7841/ksbbj.2017.32.3.169
이용수
초록· 키워드
오류제보하기
Butyric acid (C4 carboxylic acid) is used as an important compound in food, pharmaceutical, and chemical industries. Currently, butyric acid is mainly produced at the industrial scale through the petrochemical processes. Biobased butyric acid has also gained attention, because the consumer prefers the food and pharmaceutical ingredients that are produced through fermentation. Clostridia is one of the well-known butyric acid producers, and massively engineered for enhanced production of butyric acid. In this paper, we reviewed the metabolic pathway of clostridia, especially Clostridium acetobutylicum and Clostridium tyrobutyricum, and summarized the metabolic engineering strategies of the strains for enhanced production of butyric acid.
목차
Abstract
1. INTRODUCTION
2. C. acetobutylicum을 이용한 부티르산 생산 대사공학 전략
3. C. tyrobutyricum을 이용한 부티르산 생산 대사공학 전략
4. CONCLUSION
REFERENCES
참고문헌 (26)
참고문헌 신청
Blank-Porat, D., T. Gruss-Fischer, N. Tarasenko, Z. Malik, A. Nudelman, and A. Rephaeli (2007) The anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties. Cancer Lett. 256: 39-48.
Zhang, C., H. Yang, F. Yang, and Y. Ma (2009) Current progress on butyric acid production by fermentation. Curr. Microbiol. 59: 656-663.
Rephaeli, A., R. Zhuk, and A. Nudelman (2000) Prodrugs of butyric acid from bench to bedside: Synthetic design, mechanisms of action, and clinical applications. Drug Develop. Res. 50: 379-391.
Horton, C. E. and G. N. Bennett (2006) Ester production in E. coli and C. acetobutylicum. Enzyme. Microb. Technol. 38: 937-943.
Park, Y. C., C. E. H. Shaffer, and G. N. Bennett (2009) Microbial formation of esters. Appl. Microbiol. Biotechnol. 85: 13.
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