Usefulness of for BI-RAD category 4 or higher lesions

Jun Suk Byun; Hyeon Hwa Oh; Hye Yoon Lee; Keum Won Kim; Jin Suk Kim; Dae Sung Yoon

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자료유형: 학술저널

저자정보: Jun Suk Byun (Konyang University) Hyeon Hwa Oh (Konyang University) Hye Yoon Lee (Konyang University) Keum Won Kim (Konyang University) Jin Suk Kim (Konyang University) Dae Sung Yoon (Konyang University)

저널정보: 대한종양외과학회 KOREAN JOURNAL OF CLINICAL ONCOLOGY Korean Journal of Clinical Oncology 제13권 제1호

발행연도: 2017.6

수록면: 43 - 49 (7page)

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Purpose: As an alternative to core-needle biopsy in confirming the diagnosis of breast cancer, the usefulness of 99mTc-sestamibi scintimammography (MIBI scan) has been rarely reported. Thus, we aimed to evaluate a direct comparison between general diagnostic modalities and breast MIBI scan, which may be revealed as a potential diagnostic alternative.
Methods: In a retrospective study, 301 patients with 801 lesions, who underwent breast MIBI scan, ultrasonography, and mammography simultaneously between January 2013 and February 2015, were reviewed. All data were analyzed by McNemar and Kappa test for statistical significance.
Results: Mean age was 49.2±9.37 years old (range from 26 to 85 years old). Results of Breast MIBI scan were divided into three categories: 236 positive intensity uptakes (29.5%), 565 negative intensity uptakes (70.5%), and 67 suspicious abnormal intensity uptakes (8.4%). Pathologic reports were also allocated into four subgroups: 122 invasive cancers (15.2%), 44 non-invasive cancers (5.5%), 194 proliferative benign lesions (24.2%), and 441 non-proliferative benign lesions (55.1%). The sensitivity, specificity, positive predictive value, and negative predictive value of MIBI scan were 83.5%, 55.6%, 59.1%, and 95.2%, respectively. Specificity of MIBI scan plus general diagnostic modalities increased dramatically, up to 85.2%, compared to general modalities (6.8%).
Conclusion: In general diagnostic modalities, such as mammography and ultrasound, BI-RAD category 4 or higher lesions were performed by needle biopsy rather than observation. The outstanding specificity and negative predictive value of MIBI scan provided confident results on non-proliferative benign lesions. MIBI scan may offer an alternative diagnostic tool for “invasive” biopsy procedures.

#Breast cancer #Scintimammography #BI-RADS category 4

참고문헌 (20)

참고문헌 신청

[인터넷자원] - Korean Breast Cancer Society / / Breast cancer facts & figures 2015

[학술지(정기간행물)] - Teifke A / 2002 / Undetected malignancies of the breast: dynamic contrast-enhanced MR imaging at 1.0 T / Radiology 224 : 881 ~ 888

[학술지(정기간행물)] - Potterton AJ / 1994 / Ultrasound demonstration of small breast cancers detected by mammographic screening / Clin Radiol 49 : 808 ~ 813

[학술지(정기간행물)] - Rosenberg RD / 1998 / Effects of age, breast density, ethnicity, and estrogen replacement therapy on screening mammographic sensitivity and cancer stage at diagnosis: review of 183,134 screening mammograms in Albuquerque, New Mexico / Radiology 209 : 511 ~ 518

[학술지(정기간행물)] - Kolb TM / 2002 / Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825patient evaluations / Radiology 225 : 165 ~ 175

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