Plasma D-dimer Can Effectively Predict the Prospective Occurrence of Ascites in Advanced Schistosomiasis Japonica Patients

Xiaoying Wu; Jianwei Ren; Zulu Gao; Yun Xu; Huiqun Xie; Tingfang Li; Yanhua Cheng; Fei Hu; Hongyun Liu; Zhihong Gong; Jinyi Liang; Jia Shen; Zhen Liu; Feng Wu; Xi Sun; Zhongzheng Niu; An Ning

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자료유형: 학술저널

저자정보: Xiaoying Wu (Fudan University) Jianwei Ren (Health Department of Guard Bureau of General Office of the Communist Party of China) Zulu Gao (Jiangxi Provincial Institute of Parasitic Diseases) Yun Xu (Jiangxi Provincial Institute of Parasitic Diseases) Huiqun Xie (Jiangxi Provincial Institute of Parasitic Diseases) Tingfang Li (Schistosomiasis Control Station of Yugan County) Yanhua Cheng (Jiangxi Provincial Institute of Parasitic Diseases) Fei Hu (Jiangxi Provincial Institute of Parasitic Diseases) Hongyun Liu (Jiangxi Provincial Institute of Parasitic Diseases) Zhihong Gong (Jiangxi Provincial Institute of Parasitic Diseases) Jinyi Liang (Key Laboratory of Tropical Diseases and Control of the Ministry of Education) Jia Shen (Key Laboratory of Tropical Diseases and Control of the Ministry of Education) Zhen Liu (Key Laboratory of Tropical Diseases and Control of the Ministry of Education) Feng Wu (Key Laboratory of Tropical Diseases and Control of the Ministry of Education) Xi Sun (Key Laboratory of Tropical Diseases and Control of the Ministry of Education) Zhongzheng Niu (Claremont Graduate University) An Ning (Jiangxi Provincial Institute of Parasitic Diseases)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.55 No.2

발행연도: 2017.4

수록면: 167 - 174 (8page)

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China still has more than 30,000 patients of advanced schistosomiasis while new cases being reported consistently. D-dimer is a fibrin degradation product. As ascites being the dominating symptom in advanced schistosomiasis, the present study aimed to explore a prediction model of ascites with D-dimer and other clinical easy-achievable indicators. A case-control study nested in a prospective cohort was conducted in schistosomiasis-endemic area of southern China. A total of 291 patients of advanced schistosomiasis were first investigated in 2013 and further followed in 2014. Information on clinical history, physical examination, and abdominal ultrasonography, including the symptom of ascites was repeatedly collected. Result showed 44 patients having ascites. Most of the patients’ ascites were confined in the kidney area with median area of 20 mm2. The level of plasma D-dimer and pertinent liver function indicators were measured at the initial investigation in 2013. Compared with those without ascites, cases with ascites had significantly higher levels of D-dimer (0.71±2.44 μg/L vs 0.48±2.12 μg /L, P=0.005), as well ALB (44.5 vs 46.2, g/L) and Type IV collagen (50.04 vs 44.50 μg/L). Receiver operating characteristic curve analyses indicated a moderate predictive value of D-dimer by its own area under curve (AUC) of 0.64 (95% CI: 0.54-0.73) and the cutoff value as 0.81 μg/L. Dichotomized by the cutoff level, D-dimer along with other categorical variables generated a prediction model with AUC of 0.76 (95% CI: 0.68- 0.89). Risks of patients with specific characteristics in the prediction model were summarized. Our study suggests that the plasma D-dimer level is a reliable predictor for incident ascites in advanced schistosomiasis japonica patients.

#Schistosoma japonicum #D-dimer #ascites #prediction #schistosomiasis japonica #China

참고문헌 (31)

참고문헌 신청

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