지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 140 - 149 (10page)
이용수
초록· 키워드
오류제보하기
All pesticides must be assessed strictly whether safe or not when agricultural operators are exposed to the pesticides in farmland. A pesticide is commonly regarded as safe when estimated dermal absorption amount is lower than the acceptable operator"s exposure level (AOEL). In this study, dermal absorption rate of chlorpyrifos, a widely used organophosphate insecticide, was investigated using rat dermal tissue model. Chlorpyrifos wettable powder solved in water (250, 500 and 2,500 ppm) was applied to freshly excised rat dermal slices (341~413 μm thickness) on static Franz diffusion cells at 32℃ for 6 hours. After exposure period of 6 hours, and then washing-at residual amount of chlorpyrifos was analyzed in dermal tissues, tape strips, washing solution, washing swabs of receptor bottles and receptor fluids at 1, 2, 4, 8 and 24 hours. Chlorpyrifos was only detected in dermal tissue but not found in receptor fluid at each concentration and time point, and the absorption rate of 250, 500 and 2,500 ppm was 2.36%, 1.96% and 1.69%, respectively. The estimated exposure level of chlorpyrifos was calculated as 0.012 mg/kg bw/day. The health risk for farmers in this condition is a level of concern because the estimated exposure level is 12 times higher than AOEL 0.001 mg/kg bw/day. However, actual health risk will be alleviated than estimated because absorbed chlorpyrifos is not permeated into internal body system and only retained in skin layer.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
[학술지(정기간행물)] - Aggarwal M / 2015 / Assessment of an extended dataset of in vitro human dermal absorption studies on pesticides to determine default values, opportunities for read-across and influence of dilution on absorption / Regul Toxicol Pharmacol 72 : 58 ~ 70
[학술지(정기간행물)] - Chae SN / 2001 / Effect of toluene application to dermal on the liver injury in rats / J Biomed Lab Sci 7 : 47 ~ 51
[학술지(정기간행물)] - Desmedt B / 2015 / In vitro dermal absorption: Sample application and seal quality in a Franz diffusion cell system / Dermal Pharmacol Physiol 28 : 245 ~ 249
[학술지(정기간행물)] - Dosemeci M / 2001 / A quantitative approach for estimating exposure to pesticides in the agricultural health study / Ann Occup Hyg 46 : 245 ~ 260
[보고서] - EC (European Commission) Health and Food Safety Directorate-General / 2015 / Summary report of the standing committee on plants, animals, food and feed
[학술지(정기간행물)] - Chae SN / 2001 / Effect of toluene application to dermal on the liver injury in rats / J Biomed Lab Sci 7 : 47 ~ 51
[학술지(정기간행물)] - Desmedt B / 2015 / In vitro dermal absorption: Sample application and seal quality in a Franz diffusion cell system / Dermal Pharmacol Physiol 28 : 245 ~ 249
[학술지(정기간행물)] - Dosemeci M / 2001 / A quantitative approach for estimating exposure to pesticides in the agricultural health study / Ann Occup Hyg 46 : 245 ~ 260
[보고서] - EC (European Commission) Health and Food Safety Directorate-General / 2015 / Summary report of the standing committee on plants, animals, food and feed
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UCI(KEPA) : I410-ECN-0101-2017-510-002026342