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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.21 No.3
- 발행연도
- 2016.9
- 수록면
- 181 - 186 (6page)
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This study was designed to investigate the inhibitory effect of Gynura procumbens extract against carbohydrate digesting enzymes and its ability to ameliorate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. G. procumbens extract showed prominent α-glucosidase and α-amylase inhibitory effects. The half-maximal inhibitory concentration (IC<SUB>50</SUB>) of G. procumbens extract against α-glucosidase and α-amylase was 0.092±0.018 and 0.084±0.027 mg/mL, respectively, suggesting that the α-amylase inhibition activity of the G. procumbens extract was more effective than that of the positive control, acarbose (IC<SUB>50</SUB>=0.164 mg/mL). The increase in postprandial blood glucose levels was more significantly alleviated in the G. procumbens extract group than in the control group of STZ-induced diabetic mice. Moreover, the area under the curve significantly decreased with G. procumbens extract administration in STZ-induced diabetic mice. These results suggest that G. procumbens extract may help alleviate postprandial hyperglycemia by inhibiting carbohydrate digesting enzymes.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Kim JS / 2011 / Alpha glucosidase inhibitory effect, anti-microbial activity and UPLC analysis of Rhus verniciflua under various extract conditions / J Med Plants Res 5 : 778 ~ 783
[학술지(정기간행물)] - Palanuvej C / 2009 / In vitro glucose entrapment and alpha-glucosidase inhibition of mucilaginous substances from selected Thai medicinal plants / Sci Pharm 77 : 837 ~ 849
[학술지(정기간행물)] - Baron AD. / 1998 / Postprandial hyperglycaemia and alpha-glucosidase inhibitors / Diabetes Res Clin Pract 40 : S51 ~ S55
[학술지(정기간행물)] - Ceriello A / 2005 / Postprandial hyperglycemia and diabetes complications : is it time to treat? / Diabetes 54 : 1 ~ 7
[학술지(정기간행물)] - Lee BH / 2012 / Modulation of starch digestion for slow glucose release through"toggling"of activities of mucosal α-glucosidases / J Biol Chem 287 : 31929 ~ 31938
[학술지(정기간행물)] - Palanuvej C / 2009 / In vitro glucose entrapment and alpha-glucosidase inhibition of mucilaginous substances from selected Thai medicinal plants / Sci Pharm 77 : 837 ~ 849
[학술지(정기간행물)] - Baron AD. / 1998 / Postprandial hyperglycaemia and alpha-glucosidase inhibitors / Diabetes Res Clin Pract 40 : S51 ~ S55
[학술지(정기간행물)] - Ceriello A / 2005 / Postprandial hyperglycemia and diabetes complications : is it time to treat? / Diabetes 54 : 1 ~ 7
[학술지(정기간행물)] - Lee BH / 2012 / Modulation of starch digestion for slow glucose release through"toggling"of activities of mucosal α-glucosidases / J Biol Chem 287 : 31929 ~ 31938
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UCI(KEPA) : I410-ECN-0101-2017-594-001391844