지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 135 - 141 (7page)
이용수
초록· 키워드
오류제보하기
Propionibacterium acnes, a gram-positive, anaerobic, and aerotolerant bacterium that is found frequently in the skin as part of the human microbiome causes inflammatory acne, shoulder infection, and the contamination of medical devices. The study goals were the antibiotic resistant and molecular epidemiological characterization of the P. acnes isolates in Korea. A total of 22 P. acnes isolates originated from diverse patients were obtained from three National Culture Collections for Pathogens in South Korea. The hemolytic properties and minimum inhibitory concentrations (MIC) of five antibiotics (tetracycline, doxycycline, clindamycin, erythromycin, and minocycline) were determined. Only one isolate showed high MIC values and resistance to all five antibiotics. Genotypic characterization was achieved by multilocus sequence typing (MLST) for eight loci (aroE, guaA, tly, camp2, atpD, gmk, lepA, and sodA) and repetitive-sequence-based PCR (rep-PCR) analysis using the DiversiLab kit. MLST revealed four phylogroups that were type IA<SUB>1</SUB> (27.3%), type IA<SUB>2</SUB> (18.2%), type IB (13.6%), and type II (40.9%). Rep-PCR results demonstrated three clusters that were cluster I (39.1%), cluster II (45.5%), and cluster III (13.6%). The isolates of cluster I were part of phylogroup type IA (both IA<SUB>1</SUB> and IA<SUB>2</SUB>), and the isolates of cluster II belonged to phylogroup type II. All isolates of phylogroup type IB were hemolytic and belonged to cluster III. The results of rep-PCR clustering analysis showed a good correlation with those of MLST phylogroups, suggesting that rep-PCR could be an alternative method to track P. acnes subtype lineages.
목차
INTRODUCTION
MATERIALS & METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Cogen AL / 2008 / Skin microbiota: a source of disease or defence? / Br J Dermatol 158 : 442 ~ 455
[학술지(정기간행물)] - Fitz-Gibbon S / 2013 / Propionibacterium acnes strain populations in the human skin microbiome associated with acne / J Invest Dermatol 133 : 2152 ~ 2160
[학술지(정기간행물)] - Eishi Y / 2002 / Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis / J Clin Microbiol 40 : 198 ~ 204
[학술지(정기간행물)] - Fassi Fehri L / 2011 / Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells / Int J Med Microbiol 301 : 69 ~ 78
[학술지(정기간행물)] - Perry A / 2011 / Propionibacterium acnes : infection beyond the skin / Expert Rev Anti Infect Ther 9 : 1149 ~ 1156
[학술지(정기간행물)] - Fitz-Gibbon S / 2013 / Propionibacterium acnes strain populations in the human skin microbiome associated with acne / J Invest Dermatol 133 : 2152 ~ 2160
[학술지(정기간행물)] - Eishi Y / 2002 / Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis / J Clin Microbiol 40 : 198 ~ 204
[학술지(정기간행물)] - Fassi Fehri L / 2011 / Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells / Int J Med Microbiol 301 : 69 ~ 78
[학술지(정기간행물)] - Perry A / 2011 / Propionibacterium acnes : infection beyond the skin / Expert Rev Anti Infect Ther 9 : 1149 ~ 1156
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UCI(KEPA) : I410-ECN-0101-2017-475-001400560