지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 84 - 92 (9page)
이용수
초록· 키워드
오류제보하기
The striking increase in colorectal cancer (CRC) has shown the great fatality in Korea for more than 15 years. The leading edge of this rising incidence rate is mainly due to the people"s dietary changes in Korea. Some studies have reported that the dietary fiber does not have significant cytotoxic effects on CRC cells, which contrasts to the effects of probiotics. It gives a positive evaluation that the nonpathogenic spore-forming Bacillus species among the probiotics including fermented bacteria might have optimistic effects on CRC incidence rate. Recently, we isolated Bacillus lentus (BL) from Korean soybean fermented food. BL showed the cytotoxic effect on human colon carcinoma cell lines HCT116 and SW480. Interestingly, BL did not have effect on human dermal fibroblast cells and human hepatoma cell line HepG2. It suggested that BL has the target cell-specific cytotoxicity toward human colon carcinoma cells. To clarify the death signaling pathway underlying the BL-induced apoptosis in cancer cells, we analyzed the expression of caspases, Bax and Bcl-2 by western blotting. The apoptotic effects by cytotoxic elements were executed by direct BL contact or membranederived vesicles isolated from BL. Treatment of HCT116 with BL activated caspase-9, -3 and increased cleavage form of poly (ADP-ribose) polymerase (PARP). However, caspase-8 activity was not increased by BL. BL-activated intrinsic pathway increased the pro-apoptotic Bax, decreased the anti-apoptotic Bcl-2 proteins on mitochondria, disrupted the mitochondrial membrane potential, and then released the cytochrome c from mitochondria. The membrane-derived vesicles (MVs) from BL induced apoptosis of the HCT116. Here, we propose that BL as a strong candidate for the development of apoptosis-specific anti-tumor agent will give great contribution to the understandings of the tumor-microbe interdisciplinary areas.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Demonstration of the current-driven Bloch line motion for novel magnetic memory operation
한국자기학회 학술연구발표회 논문개요집
2021 .07
-
Introduction of Brillouin Light Scattering for Spintronics Research
한국자기학회 학술연구발표회 논문개요집
2021 .11
-
H9 Induces Apoptosis via the Intrinsic Pathway in Non-Small-Cell Lung Cancer A549 Cells
Journal of Microbiology and Biotechnology
2015 .01
-
The Protein Crystallography Beamlines at the Pohang Light Source II
Biodesign
2017 .03
-
A549 폐암세포에서 미토콘드리아 경로를 통한 개똥쑥 추출물의 apoptosis 유도 효과
생명과학회지
2016 .08
-
Radical of ideals in BL-algebras
ANNALS OF FUZZY MATHEMATICS AND INFORMATICS
2017 .09
-
AGS 인체 위암세포에서 황흑산에 의한 ROS 생성 및 caspase 활성 의존적 apoptosis 유발
생명과학회지
2015 .11
-
Reactive oxygen species-dependent apoptosis induction by water extract of Citrus unshiu peel in MDA-MB-231 human breast carcinoma cells
Nutrition Research and Practice
2018 .04
-
Reactive oxygen species-dependent apoptosis induction by water extract of Citrus unshiu peel in MDA-MB-231 human breast carcinoma cells
Nutrition Research and Practice
2018 .04
-
Picropodophyllotoxin Induces G1 Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway
Journal of Microbiology and Biotechnology
2021 .12
-
대장암세포주 HT29에서의 Treculia africana 추출물의 항산화 및 항암 활성 분석
생명과학회지
2015 .05
-
포도껍질 추출물이 인체유방암세포 사멸에 미치는 영향
동아시아식생활학회지
2015 .02
-
Induction of Apoptosis of DK-5-62, a Novel (-)-Catechin Derivative Through MAPKs Signaling Pathway in HCT116 Cells
대한화학회지
2022 .08
-
Physiological Response of Escherichia coli W3110 and BL21 to the Aerobic Expression of Vitreoscilla Hemoglobin
Journal of Microbiology and Biotechnology
2020 .01
-
HY253, a Novel Decahydrofluorene Analog, Induces Apoptosis via Intrinsic Pathway and Cell Cycle Arrest in Liver Cancer HepG2 Cells
Journal of Microbiology and Biotechnology
2015 .01
-
PM Assisted, Brushless Wound Rotor Synchronous Machine
Journal of Magnetics
2016 .09
-
On symmetric bi-derivations of $BL$-algebras
ANNALS OF FUZZY MATHEMATICS AND INFORMATICS
2020 .01
-
Neuroprotective effects of urolithin A on H₂O₂-induced oxidative stress-mediated apoptosis in SK-N-MC cells
Nutrition Research and Practice
2020 .02
-
Neuroprotective effects of urolithin A on H₂O₂-induced oxidative stress-mediated apoptosis in SK-N-MC cells
Nutrition Research and Practice
2020 .02
-
사간탕 처리에 의한 AGS 인체 위암세포의 caspase 활성 의존적 apoptosis 유발
생명과학회지
2015 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-475-000837687