지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 299 - 308 (10page)
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초록· 키워드
오류제보하기
Hepatic encephalopathy (HE, also knownas portosystemic encephalopathy) is a serious neuropsychiatric complication as a result of liver dysfunction. This disease encompasses a broad range of symptoms characterized by personality changes, intellectual impairment, and a depressed level of consciousness with varying severity. Patients with HE have high mortality and poor quality of life, however, burden of this disease is increasing. Therefore, this review focused on the pathogenesis and diagnosis of HE. Although the precise molecular mechanisms are unclear, HE is the synergistic effects of excess ammonia and inflammation cause astrocyte swelling and cerebral edema. It is theorized that neurotoxic substances, including ammonia and manganese, may gain entry into the brain in the setting of liver failure. Also, it is known that neurosteroids, altered neurotransmission and oxidative stress involved in the pathogenesis of HE. The diagnosis of HE performed by a number of investigations, including clinical scales, neuropsychometric tests, neurophysiologic tests and brain imaging. Clinically, HE is best diagnosed by excluding other acute and chronic causes of altered mental status and confirming the diagnosis by a positive response to empiric treatment.
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