지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.5
- 수록면
- 135 - 139 (5page)
이용수
초록· 키워드
오류제보하기
Scrophularia ningpoensis hemsl has been traditionally used in China and Vietnam for treatment of bacteria, atopy, pimple, tonsillitis, angina and encephalitis for a long time. The main objectives of this study were to evaluate the antibacterial activity of the Scrophularia ningpoensis hemsl extract on biofilm formation of Klebsiella pneumoniae. Antibacterial activity was conducted using disc diffusion assay and minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) were determined using the broth micro dilution method in accordance to Clinical and Laboratory Standards Institute guidelines(CLSI). Furthermore, cytotoxicity on L929 were assessed using animal cell culture for the proliferation test(MTT cell assay) and the biofilm forming capacity of the K. pneumoniae were determined using the colony forming unit (CFU) assay. The extract exhibited considerable antibacterial activity. K. pneumoniae was susceptible to the extract with the MIC and MBC of 0.1875 and 1.5 ㎎/㎖ respectively. Cytoxicity test in L929 showed no sign of toxicity at the concentration of 0.75㎎/㎖ and at the same concentration the extract caused inhibition of bacterial biofilm formation. The extract of Scrophularia ningpoensis hemsl possesses an in vitro antibacterial antibiofilm activities against K. pneumoniae, with no sign of cytoxicity on L929.
목차
Abstract
Ⅰ. Introduction
Ⅱ. Material and Methods
Ⅲ. Results
Ⅳ. Conclusions
REFERENCES
참고문헌 (16)
참고문헌 신청
Gowsiya Shaik, Sujatha and Santosh Kumar Mehar, "Medicinal plants as source of antibacterial agents to counter Klebsiella pneumoniae", Journal of Applied Pharmaceutical Science Vol. 4(01), pp. 135-147, January, 2014.
Wu HS, Wang FD, Tseng CP, Wu TH, Lin YT, Fung CP, "Characteristics of healthcare associated and community acquired Klebsiella pneumoniae bacteremia in Taiwan", J Infect, Vol. 64, pp. 162-168, 2012.
Sneh Lata, Geetika Sharma and Harmanjot Kaur Sandhu, “Antibacterial Properties of Various Medicinal Plants Extracts against Klebsiella Sp”. International Research Journal of Environment Sciences, Vol. 3(10), pp. 75-78, October 2014.
David L. Paterson, Wen-Chien Ko, Anne Von Gottberg, Sunita Mohapatra, Jose Maria Casellas, "Implications of Extended-Spectrum-Lactamase Production in Nosocomial Infections", Ann Intern Med. Vol. 140 pp. 26-32, 2004.
Neethu H, Tincy K.T, Jayakumaran A.N, "Comparative Study on the Synergistic Action of Garlic Synthesized and Citrate Capped Silver Nanoparticles with β-Penem Antibiotics" Nanotechnology Vol. 2013, pp. 6, 2013.
Wu HS, Wang FD, Tseng CP, Wu TH, Lin YT, Fung CP, "Characteristics of healthcare associated and community acquired Klebsiella pneumoniae bacteremia in Taiwan", J Infect, Vol. 64, pp. 162-168, 2012.
Sneh Lata, Geetika Sharma and Harmanjot Kaur Sandhu, “Antibacterial Properties of Various Medicinal Plants Extracts against Klebsiella Sp”. International Research Journal of Environment Sciences, Vol. 3(10), pp. 75-78, October 2014.
David L. Paterson, Wen-Chien Ko, Anne Von Gottberg, Sunita Mohapatra, Jose Maria Casellas, "Implications of Extended-Spectrum-Lactamase Production in Nosocomial Infections", Ann Intern Med. Vol. 140 pp. 26-32, 2004.
Neethu H, Tincy K.T, Jayakumaran A.N, "Comparative Study on the Synergistic Action of Garlic Synthesized and Citrate Capped Silver Nanoparticles with β-Penem Antibiotics" Nanotechnology Vol. 2013, pp. 6, 2013.
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UCI(KEPA) : I410-ECN-0101-2017-004-000735447