지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 163 - 171 (9page)
이용수
초록· 키워드
오류제보하기
As most infections by the helminth parasite elicit the recruitment of CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP> T (T<SUB>reg</SUB>) cells, many scientists have suggested that these cells could be used for the treatment of immune-mediated inflammation and associated diseases. In order to investigate the distribution and alteration of activated T<SUB>reg</SUB> cells, we compared the expression levels of T<SUB>reg</SUB> cell activation markers in the ileum and gastrocnemius tissues 1, 2, and 4 weeks after infection. The number of T<SUB>reg</SUB> cells was monitored using GFP-coded Foxp3 transgenic mice. In mice at 1 week after Trichinella spiralis infection, the number of activated Treg cells was higher than in the control group. In mice at 2 weeks after infection, there was a significant increase in the number of cells expressing Foxp3 and CTLA-4 when compared to the control group and mice at 1 week after infection. At 4 weeks after infection, T. spiralis was easily identifiable in nurse cells in mouse muscles. In the intestine, the expression of Gzmb and Klrg1 decreased over time and that of Capg remained unchanged for the first and second week, then decreased in the 4th week. However, in the muscles, the expression of most chemokine genes was increased due to T. spiralis infection, in particular the expression levels of Gzmb, OX40, and CTLA-4 increased until week 4. In addition, increased gene expression of all chemokine receptors in muscle, CXCR3, CCR4, CCR5, CCR9, and CCR10, was observed up until the 4th week. In conclusion, various chemokine receptors showed increased expressions combined with recruitment of T<SUB>reg</SUB> cells in the muscle tissue.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (39)
참고문헌 신청
Julia V, Macia L, Dombrowicz D. The impact of diet on asthma and allergic diseases. Nat Rev Immunol 2015; 15: 308-322.
Loke P, Lim YA. Helminths and the microbiota: parts of the hygiene hypothesis. Parasite Immunol 2015; 37: 314-323.
Flohr C, Quinnell RJ, Britton J. Do helminth parasites protect against atopy and allergic disease? Clin Exp Allergy 2009; 39: 20-
4. Fogarty AW. What have studies of non-industrialized countries told us about the cause of allergic disease? Clin Exp Allergy 2015; 45: 87-93.
Zaph C, Cooper PJ, Harris NL. Mucosal immune responses following intestinal nematode infection. Parasite Immunol 2014; 36: 439-452.
Loke P, Lim YA. Helminths and the microbiota: parts of the hygiene hypothesis. Parasite Immunol 2015; 37: 314-323.
Flohr C, Quinnell RJ, Britton J. Do helminth parasites protect against atopy and allergic disease? Clin Exp Allergy 2009; 39: 20-
4. Fogarty AW. What have studies of non-industrialized countries told us about the cause of allergic disease? Clin Exp Allergy 2015; 45: 87-93.
Zaph C, Cooper PJ, Harris NL. Mucosal immune responses following intestinal nematode infection. Parasite Immunol 2014; 36: 439-452.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
국내 임상시험 대상자 모집 광고문 내용 분석과 평가
병원약사회지
2022 .05
-
Muscle stem cell senescence, muscle regeneration and Senolytics
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Effects of Whole Body Electromyostimulation on Muscle Activity and Muscle Thickness of Rectus Femoris, and Muscle Thickness of Abdominis Muscle in Healthy Adults
한국전문물리치료학회지
2019 .01
-
경피적전기신경자극 적용 시 적용강도가 성인남성의 위등세모근의 근활성도와 근경도에 미치는 영향
대한통합의학회지
2022 .02
-
Coherence Analysis of Jaw and Neck Muscle Coordination during Chewing in Healthy Adults
Journal of Oral Medicine and Pain
2023 .12
-
Recent Advances in Skeletal Muscle Stem Cells for Duchenne Muscular Dystrophy Treatment
Hanyang Medical Reviews
2015 .01
-
Study on Hand Greater Yang Skin from the Viewpoint of Human Anatomy
대한한의학회지
2018 .12
-
테이핑 또는 시각적 피드백을 병행한 드로우-인 교각운동이 복부 근활성도에 미치는 영향
대한통합의학회지
2024 .05
-
Association between Age and Trunk Muscle Area and Density in Patients with Spinal Metastases
Asian Spine Journal
2022 .10
-
몸통 안정화 근육과 보행요소의 상관관계
PNF and movement
2019 .01
-
The elusive role of myostatin signaling for muscle regeneration and maintenance of muscle and bone homeostasis
Osteoporosis and Sarcopenia
2023 .03
-
Satellite cell distribution in the medial rectus muscle in cadavers
고신대학교 의과대학 학술지
2024 .09
-
전기자극 조건에 따른 근육 세포에 미치는 영향과 반응
의공학회지
2017 .01
-
지지면과 무릎관절 각도에 따른 교각운동이 복부근육의 두께에 미치는 영향
대한물리치료과학회지
2018 .01
-
Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research
Endocrinology and Metabolism
2022 .06
-
Development of therapeutic candidates for aging-related muscle atrophy
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Muscle pathology in neuromuscular disorders
Annals of Clinical Neurophysiology
2020 .01
-
The effects of elbow joint angle and resistance point on muscle activation of the contralateral shoulder muscles while performing the ulnar thrust PNF pattern exercise
대한물리의학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-513-002838354