지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 95 - 100 (6page)
- DOI
- 10.15188/kjopp.2016.04.30.2.95
이용수
초록· 키워드
오류제보하기
The aim of the present study is to investigate the hypotensive effect of Mantidis ootheca (WMO), Rosa laevigata (WIC), and Imperata cylindrica (WRL) in renovascular hypertension rats. Experimental hypertension model is 2-kidney and 1-clip (2K1C) induced rats. 2K1C rats were treated with WMO, WIC, and WRL at dose of 100 mg/kg/day orally for 3 weeks, respectively. Treatment groups with WMO, WIC, and WRL significantly lowered blood pressure. Interestingly, WMO, WIC, and WRL ameliorated endothelium-dependent and independent vascular relaxation in the phenylephrine-precontracted thoracic aorta in hypertension models. In addition, 2K1C-induced hypertension model increased plasma renin activity, however, WMO, WIC, and WRL attenuated those activities. These results suggest that WMO, WIC, and WRL ameliorates vascular dysfunction in 2K1C-induced hypertension models via the regulation of nitric oxide and renin-angiotensin-aldosterone system.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (23)
참고문헌 신청
Kang, H.T., Lee, J., Linton, J.A., Park, B.J., Lee, Y.J. Trends in the prevalence of chronic kidney disease in Korean adults: the Korean National Health and Nutrition Examination Survey from 1998 to 2009. Nephrol Dial Transplant. 28(4):927-936, 2013.
Park, J.B., Schiffrin, E.L. Effects of antihypertensive therapy on hypertensive vascular disease. Curr Hypertens Rep. 2: 280-288, 2000
Wickman, A., Andersson, I.J., Jia, J., Hedin, L., Bergström, G. Endothelial nitric oxide synthase protein is reduced in the renal medulla of two-kidney, one-clip hypertensive rats. J Hypertens. 19(9):1665-1673, 2001.
Hsueh, W.A., Quinones, M.J., Creager, M.A. Endothelium in insulin resistance and diabetes. Diabetes Rev. 5: 343-352, 1997.
Ruslan, R., Fabio, V., Sanjiv, K., Daniel, P., Charles D., Shawn, E., David, F., Stephen, M. eNOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J Endocrinol. 210(3):271-284, 2011.
Park, J.B., Schiffrin, E.L. Effects of antihypertensive therapy on hypertensive vascular disease. Curr Hypertens Rep. 2: 280-288, 2000
Wickman, A., Andersson, I.J., Jia, J., Hedin, L., Bergström, G. Endothelial nitric oxide synthase protein is reduced in the renal medulla of two-kidney, one-clip hypertensive rats. J Hypertens. 19(9):1665-1673, 2001.
Hsueh, W.A., Quinones, M.J., Creager, M.A. Endothelium in insulin resistance and diabetes. Diabetes Rev. 5: 343-352, 1997.
Ruslan, R., Fabio, V., Sanjiv, K., Daniel, P., Charles D., Shawn, E., David, F., Stephen, M. eNOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J Endocrinol. 210(3):271-284, 2011.
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