지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.3
- 수록면
- 21 - 33 (13page)
이용수
초록· 키워드
오류제보하기
Objectives: Banhasasim-tang (BHSST) has been used for the treatment of the digestive and gastric diseases in Korea. This study aimed to investigate the stability and biological activities of BHSST decoction depending on the preservation temperature and periods.
Methods: BHSST decoction was preserved at room temperatures (R/T, 23±1℃) or refrigeration (4℃) for 0, 30, 60 and 90 days. To evaluate the stability of BHSST decoction, pH and sugar content were estimated. In addition, high-performance liquid chromatography (HPLC) analysis was performed to determine marker compounds of BHSST decoction. To evaluate anti-inflammatory effect, nitric oxide (NO) and prostaglandin E2 (PGE2) productions were measured in LPS-stimulated RAW 264.7 macrophages. Antioxidant activity was examined using the assays for 3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) and 1-1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities.
Results: There was no change in pH and sugar content depending on the preservation temperature and periods of BHSST decoction. Among the major components of BHSST, contents of liquiritin, baicalein and wogonin was reduced time-dependently both at R/T and 4℃. Inhibitory effects of BHSST decoction on NO and PGE2 productions were slightly decreased in a time-dependent manner by 90 days of preservation. In addition, BHSST decoction maintained ABTS and DPPH radical scavenging activities by 60 days while significantly reducing the activities in 90 days of preservation at R/T. By contrast, BHSST decoction had no significant change of ABTS and DPPH radical scavenging activities by 90 days at 4℃.
Conclusions: Our results suggest that the stability and efficacy of BHSST decoction are maintained for 60 days at 4℃ rather than R/T.
Methods: BHSST decoction was preserved at room temperatures (R/T, 23±1℃) or refrigeration (4℃) for 0, 30, 60 and 90 days. To evaluate the stability of BHSST decoction, pH and sugar content were estimated. In addition, high-performance liquid chromatography (HPLC) analysis was performed to determine marker compounds of BHSST decoction. To evaluate anti-inflammatory effect, nitric oxide (NO) and prostaglandin E2 (PGE2) productions were measured in LPS-stimulated RAW 264.7 macrophages. Antioxidant activity was examined using the assays for 3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) and 1-1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities.
Results: There was no change in pH and sugar content depending on the preservation temperature and periods of BHSST decoction. Among the major components of BHSST, contents of liquiritin, baicalein and wogonin was reduced time-dependently both at R/T and 4℃. Inhibitory effects of BHSST decoction on NO and PGE2 productions were slightly decreased in a time-dependent manner by 90 days of preservation. In addition, BHSST decoction maintained ABTS and DPPH radical scavenging activities by 60 days while significantly reducing the activities in 90 days of preservation at R/T. By contrast, BHSST decoction had no significant change of ABTS and DPPH radical scavenging activities by 90 days at 4℃.
Conclusions: Our results suggest that the stability and efficacy of BHSST decoction are maintained for 60 days at 4℃ rather than R/T.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (37)
참고문헌 신청
Jang IS, Yang CS, Lee SD, Han CH. A review of herbal medicine products associated with toxic events in Korea. J Korean Oriental Med. 2007;28(1):1-10.
Man SC, Durairajan SS, Kum WF, Lu JH, Huang JD, Cheng CF, et al. Systematic review on the efficacy and safety of herbal medicines for Alzheimer’s disease. J Alzheimer’s Dis. 2008;14(2):209-23.
Son JY, Shin JW, Son CG. Stability study for herbal drug according to storage conditions and periods. J Korean Oriental Med. 2009;30(2): 127-32.
Jang JK. Shang HL. Seoul:DS print. 1984:188,201-2, 205-6.
Jang JK. Geumgweyolag. Seoul:DS print. 1984:360, 415.
Man SC, Durairajan SS, Kum WF, Lu JH, Huang JD, Cheng CF, et al. Systematic review on the efficacy and safety of herbal medicines for Alzheimer’s disease. J Alzheimer’s Dis. 2008;14(2):209-23.
Son JY, Shin JW, Son CG. Stability study for herbal drug according to storage conditions and periods. J Korean Oriental Med. 2009;30(2): 127-32.
Jang JK. Shang HL. Seoul:DS print. 1984:188,201-2, 205-6.
Jang JK. Geumgweyolag. Seoul:DS print. 1984:360, 415.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
한약처방 연구의 전탕의 적절성에 관한 조사 - 《東醫寶鑑》 중 大黃이 配伍된 처방을 중심으로
한약정보연구회지
2015 .09
-
보관 온도 및 기간에 따른 마황탕 전탕액의 지표 성분 함량, 항염증 및 항산화 활성 비교
생약학회지(Korean Journal of Pharmacognosy)
2018 .06
-
다섯 가지 다용한약처방의 전탕 전후 유해 중금속 이행률 조사
대한예방한의학회지
2015 .12
-
Development of Hazardous Materials Management Standard for Decoction Type of Personalized Herbal Medicine
Journal of Pharmacopuncture
2020 .01
-
2012년 첩약 건강보험 급여화 시범사업 정책 결정에 관한 연구
대한예방한의학회지
2020 .01
-
교통사고 이후 발생한 기능성 위장관장애에 대한 반하사심탕 투여 : 연속증례
대한한방내과학회지
2018 .01
-
≪상한론≫ 탕제에서 한약 하루 먹는 량 최대와 최소 비율에 근거한 복용량 1 량(兩) 교정
대한본초학회지(본초분과학회지)
2019 .01
-
Satisfaction and Perceived Effectiveness on Herbal Decoctions for Postpartum Care: a cross-sectional survey of mother’s experience
Journal of Pharmacopuncture
2023 .06
-
미생물에 대한 항균효과를 이용한 한약 전탕팩의 유효기한 연구
대한한의학회지
2020 .06
-
『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 준거하여 한약 투여 후 호전된 갱년기 증후군 1례 임상 보고
대한상한금궤의학회지
2016 .01
-
『傷寒論』의 四方?四神湯 中 朱鳥湯의 不在에 관한 고찰
한국의사학회지
2021 .11
-
중국 및 한국 Database에서의 위식도 역류질환에 대한 반하사심탕의 효과에 대한 최근 10년간의 연구경향
대한한방내과학회지
2020 .01
-
가미온청음(加味溫淸飮) 추출물이 항염증, 항산화 및 미백에 미치는 효과
대한침구의학회지
2015 .01
-
갈근탕 혼합단미엑스제 및 전탕액의 성분 및 생리활성 비교 연구
동의생리병리학회지
2019 .01
-
Effects of Herbal Medicine (Gan Mai Da Zao Decoction) on Several Types of Neuropsychiatric Disorders in an Animal Model: A Systematic Review - Herbal medicine for animal studies of neuropsychiatric diseases -
Journal of Pharmacopuncture
2017 .01
-
고지혈성 급성 췌장염에 대한 대시호탕의 효과 : 체계적 문헌고찰과 메타분석
대한한방내과학회지
2020 .01
-
LC-MS/MS를 이용한 반하사심탕 물 추출물 중 13종 성분의 함량분석
생약학회지(Korean Journal of Pharmacognosy)
2016 .03
-
사상의학에서의 탕제 복용법에 관한 문헌적 고찰
JSCM : Journal of Sasang constitutional medicine
2017 .01
-
불현성 갑상선기능저하증에 대한 이선탕 가미 처방 투여 경과 : 증례보고
대한한방내과학회지
2018 .01
-
가미소요산 전탕팩의 보관 온도 및 기간에 따른 지표 성분 함량 및 항염증 효능 비교 연구
대한한의학회지
2018 .03
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-519-002699437