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A Novel Single Nucleotide Polymorphism of the Leptin Receptor Gene Associated with Backfat Thickness in Duroc Pigs
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Type
Academic journal
Author
Kyung-Tai Lee (Rural Development Administration) Hae-Young Lee (Rural Development Administration) Bong-Hwan Choi (Rural Development Administration) Jong-Joo Kim (Yeungnam University) Tae-Hun Kim (Rural Development Administration)
Journal
Korean Society Of Life Science Journal of Life Science Vol.26 No.1 KCI Accredited Journals
Published
2016.1
Pages
1 - 7 (7page)

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A Novel Single Nucleotide Polymorphism of the Leptin Receptor Gene Associated with Backfat Thickness in Duroc Pigs
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Fatness is one of the most important economic traits in pigs. The leptin receptor (LEPR) gene may be a potential candidate for the fatness quantitative trait locus (QTL) on porcine chromosome 6, due to its position and physiological role. Thus, this study was carried out to evaluate the associations between structural variants in the LEPR gene and economic traits in pigs. We obtained an approximately 114-kb sequence containing the complete genomic DNA of the porcine LEPR gene, using shotgun sequencing of a bacterial artificial chromosome clone. We report the complete genomic structure of the porcine LEPR gene. Dozens of transcription factor-binding sites were found in the 1.2 kb upstream region from the transcription start point. An association study was performed with 550 Duroc pigs for 24 single-nucleotide polymorphisms (SNPs), including 6 SNPs within exons and 18 SNPs within the putative 5‘ regulatory region of the porcine LEPR gene. Among them, one SNP (-790C/G) was significantly associated with backfat thickness and lean meat percentage, whereas the others, including two SNPs with missense polymorphisms, had no effect on any phenotype. These results suggest that SNP -790C/G may be a useful marker for genetic improvements of fatness and leanness in Duroc pigs.
#Economic trait #leptin receptor #pig #single nucleotide polymorphism

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Introduction
Materials and Methods
Results and Discussion
References
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Arnyasi, M., Grindflek, E., Javor, A. and Lien, S. 2006. Investigation of two candidate genes for meat quality traits in a quantitative trait locus region on SSC6: the porcine short heterodimer partner and heart fatty acid binding protein genes. J. Anim. Breed. Genet. 123, 198-203. google schola Chen, C. C., Chang, T. and Su, H. Y. 2004. Characterization of porcine leptin receptor polymorphisms and their association with reproduction and production traits. Anim. Biotechnol. 15, 89-102. google schola de Koning, D. J., Rattink, A. P., Harlizius, B., van Arendonk, J. A., Brascamp, E. W. and Groenen, M. A. 2000. Genome-wide scan for body composition in pigs reveals important role of imprinting. Proc. Natl. Acad. Sci. USA 97, 7947-7950. google schola Friedman, J. M. and Halaas J. L. 1998. Leptin and the regulation of body weight in mammals. Nature 395, 763-770. google schola Friedman, J. M. 2002. The function of leptin in nutrition, weight, and physiology. Nutr. Rev. 60, 85-87. google schola

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