메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색
질문

논문 기본 정보

자료유형
학술저널
저자정보
Ji Hyun Cheon (Sungkyunkwan University) Sun Young Kim (Duksung Women’s University) Ji Yeon Son (Sungkyunkwan University) Ye Rim Kang (Sungkyunkwan University) Ji Hye An (Sungkyunkwan University) Ji Hoon Kwon (Sungkyunkwan University) Ho Sub Song (Sungkyunkwan University) Aree Moon (Duksung Women’s University) Byung Mu Lee (Sungkyunkwan University) Hyung Sik Kim (Sungkyunkwan University)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.32 No.1
발행연도
2016.1
수록면
47 - 56 (10page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색
질문

초록· 키워드

오류제보하기
The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr) and blood urea nitrogen (BUN), are frequently used to diagnose AKI. However, these biomarkers increase only after significant structural damage has occurred. Recent efforts have focused on identification and validation of new noninvasive biomarkers for the early detection of AKI, prior to extensive structural damage. Furthermore, AKI biomarkers can provide valuable insight into the molecular mechanisms of this complex and heterogeneous disease. Our previous study suggested that pyruvate kinase M2 (PKM2), which is excreted in the urine, is a sensitive biomarker for nephrotoxicity. To appropriately and optimally utilize PKM2 as a biomarker for AKI requires its complete characterization. This review highlights the major studies that have addressed the diagnostic and prognostic predictive power of biomarkers for AKI and assesses the potential usage of PKM2 as an early biomarker for AKI. We summarize the current state of knowledge regarding the role of biomarkers and the molecular and cellular mechanisms of AKI. This review will elucidate the biological basis of specific biomarkers that will contribute to improving the early detection and diagnosis of AKI.

목차

INTRODUCTION
CURRENTLY PROPOSED BIOMARKERS FOR EARLY DETECTION OF AKI
POSSIBLE ROLE OF PKM2 IN AKI
CONCLUSIONS
REFERENCES

참고문헌 (79)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0

UCI(KEPA) : I410-ECN-0101-2016-513-002333925