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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 47 - 56 (10page)
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The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr) and blood urea nitrogen (BUN), are frequently used to diagnose AKI. However, these biomarkers increase only after significant structural damage has occurred. Recent efforts have focused on identification and validation of new noninvasive biomarkers for the early detection of AKI, prior to extensive structural damage. Furthermore, AKI biomarkers can provide valuable insight into the molecular mechanisms of this complex and heterogeneous disease. Our previous study suggested that pyruvate kinase M2 (PKM2), which is excreted in the urine, is a sensitive biomarker for nephrotoxicity. To appropriately and optimally utilize PKM2 as a biomarker for AKI requires its complete characterization. This review highlights the major studies that have addressed the diagnostic and prognostic predictive power of biomarkers for AKI and assesses the potential usage of PKM2 as an early biomarker for AKI. We summarize the current state of knowledge regarding the role of biomarkers and the molecular and cellular mechanisms of AKI. This review will elucidate the biological basis of specific biomarkers that will contribute to improving the early detection and diagnosis of AKI.
목차
INTRODUCTION
CURRENTLY PROPOSED BIOMARKERS FOR EARLY DETECTION OF AKI
POSSIBLE ROLE OF PKM2 IN AKI
CONCLUSIONS
REFERENCES
참고문헌 (79)
참고문헌 신청
Van Biesen, W., Vanholder, R. and Lamiere, N. (2006) Defining acute renal failure: RIFLE and beyond. Clin. J. Am. Soc. Nephrol., 1, 1314-1319.
Basile, D.P., Anderson, M.D. and Sutton, T.A. (2012) Pathophysiology of acute kidney injury. Compr. Physiol., 2, 1303-1353.
Ricci, Z., Cruz, D.N. and Ronco, C. (2011) Classification and staging of acute kidney injury: beyond the RIFLE and AKIN criteria. Nat. Rev. Nephrol., 7, 201-208.
Thadhani, R., Pascual, M. and Bonventre, J.V. (1996) Acute renal failure. N. Engl. J. Med., 334, 1448-1460.
Ympa, Y.P., Sakr, Y., Reinhart, K. and Vincent, J.L. (2005) Has mortality from acute renal failure decreased? A systematic review of the literature. Am. J. Med., 118, 827-832.
Basile, D.P., Anderson, M.D. and Sutton, T.A. (2012) Pathophysiology of acute kidney injury. Compr. Physiol., 2, 1303-1353.
Ricci, Z., Cruz, D.N. and Ronco, C. (2011) Classification and staging of acute kidney injury: beyond the RIFLE and AKIN criteria. Nat. Rev. Nephrol., 7, 201-208.
Thadhani, R., Pascual, M. and Bonventre, J.V. (1996) Acute renal failure. N. Engl. J. Med., 334, 1448-1460.
Ympa, Y.P., Sakr, Y., Reinhart, K. and Vincent, J.L. (2005) Has mortality from acute renal failure decreased? A systematic review of the literature. Am. J. Med., 118, 827-832.
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UCI(KEPA) : I410-ECN-0101-2016-513-002333925