Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction

Sung Kook Chun; Kristina Go; Ming-Jim Yang; Ivan Zendejas; Kevin E. Behrns; Jae-Sung Kim

Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction

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Type: Academic journal

Author: Sung Kook Chun (University of Florida) Kristina Go (University of Florida) Ming-Jim Yang (University of Florida) Ivan Zendejas (University of Florida) Kevin E. Behrns (University of Florida) Jae-Sung Kim (University of Florida)

Journal: The Korean Society Of Toxicology Toxicological Research Vol.32 No.1 KCI Accredited Journals SCOPUS

Published: 2016.1

Pages: 35 - 46 (12page)

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Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction

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No-flow ischemia occurs during cardiac arrest, hemorrhagic shock, liver resection and transplantation. Recovery of blood flow and normal physiological pH, however, irreversibly injures the liver and other tissues. Although the liver has the powerful machinery for mitochondrial quality control, a process called mitophagy, mitochondrial dysfunction and subsequent cell death occur after reperfusion. Growing evidence indicates that reperfusion impairs mitophagy, leading to mitochondrial dysfunction, defective oxidative phosphorylation, accumulation of toxic metabolites, energy loss and ultimately cell death. The importance of acetylation/deacetylation cycle in the mitochondria and mitophagy has recently gained attention. Emerging data suggest that sirtuins, enzymes deacetylating a variety of target proteins in cellular metabolism, survival and longevity, may also act as an autophagy modulator. This review highlights recent advances of our understanding of a mechanistic correlation between sirtuin 1, mitophagy and ischemic liver injury.

#Autophagy #Mitochondria #Liver #Ischemia/Reperfusion #Acetylation

INTRODUCTION
THE LIVER
LIVER SURGERY AND I/R INJURY
MECHANISMS OF I/R INJURY
AUTOPHAGY
MITOPHAGY
MITOPHAGY IN LIVER I/R INJURY
SIRTUINS IN THE LIVER
ROLE OF ACETYLATION/DEACETYLATION IN AUTOPHAGY
SIRT1, AUTOPHAGY AND I/R INJURY
CONCLUSION AND FUTURE PERSPECTIVES
REFERENCES

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Mizushima, N. and Klionsky, D.J. (2007) Protein turnover viaautophagy: implications for metabolism. Annu. Rev. Nutr., 27,19-40.

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