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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
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- 1 - 7 (7page)
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Objectives : The present subacute study was designed to evaluate the effect of coenzyme Q 10 (CoQ10) in the 28 days aroclor 1254 exposure induced oxidative stress in mice brain.
Methods : Biochemical estimations of brain lipid peroxidation (LPO), reduced glutathione (GSH), and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and acetyl cholinesterase (AChE), and histopathological investigations of brain tissue were carried out.
Results : Oral exposure of aroclor 1254 (5 mg/kg) led to significant decrease in levels of GSH, and activities of SOD, CAT, GPx, and AChE, and increase in LPO. These aberrations were restored by CoQ10 (10 mg/kg, intraperitoneal injection [IP]). This protection offered was comparable to that of L-deprenyl (1 mg/kg, IP) which served as a reference standard.
Conclusions : Aroclor 1254 exposure hampers the activities of various antioxidant enzymes and induces oxidative stress in the brains of Swiss albino mice. Supplementation of CoQ10 abrogates these deleterious effects of aroclor 1254. CoQ10 also apparently enhanced acetyl cholinesterase activity which reflects its influence on the cholinergic system.
Methods : Biochemical estimations of brain lipid peroxidation (LPO), reduced glutathione (GSH), and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and acetyl cholinesterase (AChE), and histopathological investigations of brain tissue were carried out.
Results : Oral exposure of aroclor 1254 (5 mg/kg) led to significant decrease in levels of GSH, and activities of SOD, CAT, GPx, and AChE, and increase in LPO. These aberrations were restored by CoQ10 (10 mg/kg, intraperitoneal injection [IP]). This protection offered was comparable to that of L-deprenyl (1 mg/kg, IP) which served as a reference standard.
Conclusions : Aroclor 1254 exposure hampers the activities of various antioxidant enzymes and induces oxidative stress in the brains of Swiss albino mice. Supplementation of CoQ10 abrogates these deleterious effects of aroclor 1254. CoQ10 also apparently enhanced acetyl cholinesterase activity which reflects its influence on the cholinergic system.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (39)
참고문헌 신청
1. [단행본] - Wright DA / 2002 / Environmental toxicology / Cambridge University Press : 70 ~
2. [학술지(정기간행물)] - Letcher RJ / 2002 / In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis (4-chlorophenyl)-1,1-dichloroethene on 17 beta-estradiol-induced gene expression in several bioassay systems / Toxicol Sci 69 (2) : 362 ~ 372
3. [학술지(정기간행물)] - McKinney MA / 2006 / Biotransformation of polybrominated diphenyl ethers and polychlorinated biphenyls in beluga whale (Delphinapterus leucas) and rat mammalian model using an in vitro hepatic microsomal assay / Aquat Toxicol 77 (1) : 87 ~ 97
4. [학술지(정기간행물)] - Verreault J / 2005 / Chlorinated hydrocarbon contaminants and metabolites in polar bears (Ursus maritimus) from Alaska, Canada, East Greenland, and Svalbard: 1996-2002 / Sci Total Environ 351 : 369 ~ 390
5. [단행본] - US Agency for Toxic Substances and Disease Registry / 1997 / Toxicological profile for polychlorinated biphenyls / US Agency for Toxic Substances and Disease Registry : 6 ~ 23
2. [학술지(정기간행물)] - Letcher RJ / 2002 / In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis (4-chlorophenyl)-1,1-dichloroethene on 17 beta-estradiol-induced gene expression in several bioassay systems / Toxicol Sci 69 (2) : 362 ~ 372
3. [학술지(정기간행물)] - McKinney MA / 2006 / Biotransformation of polybrominated diphenyl ethers and polychlorinated biphenyls in beluga whale (Delphinapterus leucas) and rat mammalian model using an in vitro hepatic microsomal assay / Aquat Toxicol 77 (1) : 87 ~ 97
4. [학술지(정기간행물)] - Verreault J / 2005 / Chlorinated hydrocarbon contaminants and metabolites in polar bears (Ursus maritimus) from Alaska, Canada, East Greenland, and Svalbard: 1996-2002 / Sci Total Environ 351 : 369 ~ 390
5. [단행본] - US Agency for Toxic Substances and Disease Registry / 1997 / Toxicological profile for polychlorinated biphenyls / US Agency for Toxic Substances and Disease Registry : 6 ~ 23
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UCI(KEPA) : I410-ECN-0101-2016-539-002083057