Characterization of Endoplasmic Reticulum Stress and Apoptosis in Macrophages Infected with Mycobacterium tuberculosis Isolates from Korea Patients

Jung-hwan Lee; Yun-Ji Lim; Ji-Ae Choi; Ji-Ye Han; Sung Hee Cho; Sung-Man Oh; Chang-Hwa Song

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자료유형: 학술저널

저자정보: Jung-hwan Lee (Chungnam National University) Yun-Ji Lim (Chungnam National University) Ji-Ae Choi (Chungnam National University) Ji-Ye Han (Chungnam National University) Sung Hee Cho (Chungnam National University) Sung-Man Oh (Chungnam National University) Chang-Hwa Song (Chungnam National University)

저널정보: 대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY Journal of Bacteriology and Virology Vol.45 No.3

발행연도: 2015.9

수록면: 215 - 227 (13page)

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Apoptosis is an important host defense mechanism against mycobacterial infection. Recent reports suggest that links between apoptosis and endoplasmic reticulum (ER) stress are critical for the regulation of mycobacterial survival; however, the exact regulatory mechanisms are not well known. In this study, we isolated 20 Mycobacterium tuberculosis (Mtb) clinical strains from Korean patients and examined ER stress-mediated apoptosis in Mtb-infected macrophages. Most Mtb strains increased the rates of apoptosis and production of ER stress-sensing molecules in mouse macrophages, similar to Mtb H37Rv infection. Moreover, the intracellular survival of Mtb clinical isolates in macrophages was similar to that of H37Rv. Our data suggest that infection with Mtb downregulated MCP-1 and MCPIP. The regulation of MCPIP may decrease ROS production, leading to a reduction in ER stress-mediated apoptosis.

#Mycobacterium tuberculosis #ER stress #MCPIP

참고문헌 (41)

참고문헌 신청

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[학술지(정기간행물)] - Knodler LA / 2005 / The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt / J Biol Chem 280 : 9058 ~ 9064

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