지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.5
- 수록면
- 12 - 23 (12page)
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초록· 키워드
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Objective: This study aims to compare liver function indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma glutamyl transferase [GGT]) among males who work with lead, organic solvents, or both lead and organic solvents, under the permissible exposure limit (PEL).
Methods: A total of 593 (out of 2,218) male workers who agreed to share their personal health information for medical research were selected for this study. Those excluded were hepatitis B carriers, individuals exposed to occupational risk factors other than lead and organic solvents, and individuals without liver function results. The 593 were divided into five groups: a lead-exposed group, an organic solvent-exposed group exposed to trichloroethylene (TCE co-exposed solvent group), an organic solvent-exposed group not exposed to trichloroethylene (TCE non-exposed solvent group), a lead and organic solvent-exposed group (mixed exposure group), and a non-exposed group (control group). We performed a one way-analysis of variance (one way-ANOVA) test to compare the geometric means of liver function indices among the groups, using a general linear model (GLM) to adjust for age, work duration, body mass index (BMI), smoking, and alcohol intake. In addition, we performed a binary logistic regression analysis to compare the odds ratios among groups with an abnormal liver function index, according to a cut-off value.
Results: The ALT and AST of the mixed exposure group were higher than those of the other groups. The GGT of the mixed exposure group was higher than the TCE co-exposed solvent group, but there was no difference among the control group, TCE non-exposed solvent group, lead-exposed group, and mixed exposure group. The same result was evident after adjusting by GLM for age, work duration, BMI, smoking, and alcohol intake, except that ALT from the mixed exposure group showed no difference from the TCE co-exposed solvent group.
When the cut-off values of the AST, ALT, and GGT were 40 IU/L, 42 IU/L, and 63 IU/L, respectively, a logistic regression analysis showed no differences in the odds ratios of those who had an abnormal liver function index among the groups. However, if the cut-off values of the AST, ALT, and GGT were 30 IU/L, 30 IU/L, and 40 IU/L, respectively, the odds ratio of the AST in the mixed exposure group was 4.39 (95% CI 1.86-10.40) times higher than the control.
Conclusion: This study indicates that a mixed exposure to lead and organic solvents is dangerous, even if each single exposure is safe under the permissible exposure limit. Therefore, to ensure occupational health and safety in industry, a continuous efforts to study the effects from exposure to mixed chemicals is needed.
Methods: A total of 593 (out of 2,218) male workers who agreed to share their personal health information for medical research were selected for this study. Those excluded were hepatitis B carriers, individuals exposed to occupational risk factors other than lead and organic solvents, and individuals without liver function results. The 593 were divided into five groups: a lead-exposed group, an organic solvent-exposed group exposed to trichloroethylene (TCE co-exposed solvent group), an organic solvent-exposed group not exposed to trichloroethylene (TCE non-exposed solvent group), a lead and organic solvent-exposed group (mixed exposure group), and a non-exposed group (control group). We performed a one way-analysis of variance (one way-ANOVA) test to compare the geometric means of liver function indices among the groups, using a general linear model (GLM) to adjust for age, work duration, body mass index (BMI), smoking, and alcohol intake. In addition, we performed a binary logistic regression analysis to compare the odds ratios among groups with an abnormal liver function index, according to a cut-off value.
Results: The ALT and AST of the mixed exposure group were higher than those of the other groups. The GGT of the mixed exposure group was higher than the TCE co-exposed solvent group, but there was no difference among the control group, TCE non-exposed solvent group, lead-exposed group, and mixed exposure group. The same result was evident after adjusting by GLM for age, work duration, BMI, smoking, and alcohol intake, except that ALT from the mixed exposure group showed no difference from the TCE co-exposed solvent group.
When the cut-off values of the AST, ALT, and GGT were 40 IU/L, 42 IU/L, and 63 IU/L, respectively, a logistic regression analysis showed no differences in the odds ratios of those who had an abnormal liver function index among the groups. However, if the cut-off values of the AST, ALT, and GGT were 30 IU/L, 30 IU/L, and 40 IU/L, respectively, the odds ratio of the AST in the mixed exposure group was 4.39 (95% CI 1.86-10.40) times higher than the control.
Conclusion: This study indicates that a mixed exposure to lead and organic solvents is dangerous, even if each single exposure is safe under the permissible exposure limit. Therefore, to ensure occupational health and safety in industry, a continuous efforts to study the effects from exposure to mixed chemicals is needed.
목차
Abstract
Introduction
Materials and methods
Methods
Results
Discussion
References
참고문헌 (53)
참고문헌 신청
1. [인터넷자원] - National Institute for Occupational Safety and Health / / Mixed exposure research agenda
2. [학술지(정기간행물)] - Kim H / 2010 / Occupational diseases in workers exposed to organic solvents / Hanyang medical reviews 30 (4) : 313 ~ 318
3. [학술지(정기간행물)] - Baker EL / 1994 / A review of recent research on health effects of human occupational exposure to organic solvents. A critical review / J Occup Med 36 (10) : 1079 ~ 1092
4. [학술지(정기간행물)] - 박창근 / 2003 / 습관성 공업용 접착제(본드) 흡입에 의해 유발된 간염 1예 / Clinical and Molecular Hepatology 9 (2003) : 332 ~ 336
5. [학술지(정기간행물)] - Kang SK / 1991 / A study on the liver dysfunction due to dimethylformamide / Korean J Occup Environ Med 3 (1) : 58 ~ 64
2. [학술지(정기간행물)] - Kim H / 2010 / Occupational diseases in workers exposed to organic solvents / Hanyang medical reviews 30 (4) : 313 ~ 318
3. [학술지(정기간행물)] - Baker EL / 1994 / A review of recent research on health effects of human occupational exposure to organic solvents. A critical review / J Occup Med 36 (10) : 1079 ~ 1092
4. [학술지(정기간행물)] - 박창근 / 2003 / 습관성 공업용 접착제(본드) 흡입에 의해 유발된 간염 1예 / Clinical and Molecular Hepatology 9 (2003) : 332 ~ 336
5. [학술지(정기간행물)] - Kang SK / 1991 / A study on the liver dysfunction due to dimethylformamide / Korean J Occup Environ Med 3 (1) : 58 ~ 64
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UCI(KEPA) : I410-ECN-0101-2016-517-001952804