지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 27 - 31 (5page)
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초록· 키워드
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Background: Methylmercury (MeHg) easily crosses the blood?brain barrier and accumulates in the brain. Accumulated MeHg will cause neurological symptoms. We report four pediatric cases of neuropsychological findings with high blood MeHg concentrations.
Case presentation: Four children were admitted for follow-up study because their total mercury (THg) concentration in the blood was found to be high during a national survey. Case 1 was a 9-year-old female with a 16.6 μg/ℓ blood THg concentration in the survey. During admission, the blood THg, hair THg, and blood MeHg concentration(mercury indices) were 21.4 μg/ℓ, 7.2 μg/g, and 20.1 μg/ℓ, respectively. In our neuropsychological examination, cognitive impairment and attention deficit were observed. Her diet included fish intake 2?3 times per week, and she had been diagnosed with epilepsy at 3 years of age. Case 2 was a 12-year-old male with blood THg of 15.4 μg/ℓ in the survey and the mercury indices were 12.7 μg/ℓ, 5.7 μg/g, and 11.8 μg/ℓ, respectively, on admission. He was also observed to have attention-deficit/hyperactivity disorder. Case 3 was a 10-year-old male child with blood THg of 17.4 μg/ℓ in the survey, and the mercury indices on admission were 21.6 μg/ℓ, 7.5 μg/g and 21.5 μg/ℓ, respectively. In his case, mild attention deficit was observed. Case 4 was a 9-year-old male with blood THg of 20.6 μg/ℓ in the survey and the mercury indices were 18.9 μg/ℓ, 8.3 μg/g, and 14.4 μg/ℓ, respectively, on admission. Mild attention difficulty was observed.
Conclusion: We suggest that fish consumption may be the main source of MeHg exposure, and that MeHg may have been the cause of the neuropsychological deficits in these cases.
Case presentation: Four children were admitted for follow-up study because their total mercury (THg) concentration in the blood was found to be high during a national survey. Case 1 was a 9-year-old female with a 16.6 μg/ℓ blood THg concentration in the survey. During admission, the blood THg, hair THg, and blood MeHg concentration(mercury indices) were 21.4 μg/ℓ, 7.2 μg/g, and 20.1 μg/ℓ, respectively. In our neuropsychological examination, cognitive impairment and attention deficit were observed. Her diet included fish intake 2?3 times per week, and she had been diagnosed with epilepsy at 3 years of age. Case 2 was a 12-year-old male with blood THg of 15.4 μg/ℓ in the survey and the mercury indices were 12.7 μg/ℓ, 5.7 μg/g, and 11.8 μg/ℓ, respectively, on admission. He was also observed to have attention-deficit/hyperactivity disorder. Case 3 was a 10-year-old male child with blood THg of 17.4 μg/ℓ in the survey, and the mercury indices on admission were 21.6 μg/ℓ, 7.5 μg/g and 21.5 μg/ℓ, respectively. In his case, mild attention deficit was observed. Case 4 was a 9-year-old male with blood THg of 20.6 μg/ℓ in the survey and the mercury indices were 18.9 μg/ℓ, 8.3 μg/g, and 14.4 μg/ℓ, respectively, on admission. Mild attention difficulty was observed.
Conclusion: We suggest that fish consumption may be the main source of MeHg exposure, and that MeHg may have been the cause of the neuropsychological deficits in these cases.
목차
Abstract
Background
Case presentation
Conclusions
References
참고문헌 (19)
참고문헌 신청
Harada Y / 1968 / Electroencephalographic studies of Minamata disease in children / Dev Med Child Neurol 10(2):257~258
Cox C / 1989 / Dose–response analysis of infants prenatally exposed to methyl mercury: an application of a single compartment model to single-strand hair analysis / Environ Res 49(2):318~332
WHO / 2008 / Guidence for identifying populations at risk from mercury exposure
Grandjean P / 1997 / Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury / Neurotoxicol Teratol 19(6):417~428
Myers GJ / 1997 / Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles Child Development Study / Neurotoxicology 18(3):819~829
Cox C / 1989 / Dose–response analysis of infants prenatally exposed to methyl mercury: an application of a single compartment model to single-strand hair analysis / Environ Res 49(2):318~332
WHO / 2008 / Guidence for identifying populations at risk from mercury exposure
Grandjean P / 1997 / Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury / Neurotoxicol Teratol 19(6):417~428
Myers GJ / 1997 / Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles Child Development Study / Neurotoxicology 18(3):819~829
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UCI(KEPA) : I410-ECN-0101-2016-517-001953290