지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 41 - 47 (7page)
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초록· 키워드
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Objectives: The present study was designed to determine whether there is a relationship between indium compound exposure and interstitial lung damage in workers employed at indium tin oxide manufacturing and reclaiming factories in Korea.
Methods: In 2012, we conducted a study for the prevention of indium induced lung damage in Korea and identified 78 workers who had serum indium or Krebs von den Lungen-6 (KL-6) levels that were higher than the reference values set in Japan (3 μg/L and 500 U/mL, respectively). Thirty-four of the 78 workers underwent chest high-resolution computed tomography (HRCT), and their data were used for statistical analysis.
Results: Geometric means (geometric standard deviations) for serum indium, KL-6, and surfactant protein D (SP-D) were 10.9 (6.65) μg/L, 859.0 (1.85) U/mL, and 179.27 (1.81) ng/mL, respectively. HRCT showed intralobular interstitial thickening in 9 workers. A dose?response trend was statistically significant for blood KL-6 levels. All workers who had indium levels ≥50 μg/L had KL-6 levels that exceeded the reference values. However, dose?response trends for blood SP-D levels, KL-6 levels, SP-D levels, and interstitial changes on the HRCT scans were not significantly different.
Conclusions: Our findings suggest that interstitial lung changes could be present in workers with indium exposure. Further studies are required and health risk information regarding indium exposure should be communicated to workers and employers in industries where indium compounds are used to prevent indium induced lung damage in Korea.
Methods: In 2012, we conducted a study for the prevention of indium induced lung damage in Korea and identified 78 workers who had serum indium or Krebs von den Lungen-6 (KL-6) levels that were higher than the reference values set in Japan (3 μg/L and 500 U/mL, respectively). Thirty-four of the 78 workers underwent chest high-resolution computed tomography (HRCT), and their data were used for statistical analysis.
Results: Geometric means (geometric standard deviations) for serum indium, KL-6, and surfactant protein D (SP-D) were 10.9 (6.65) μg/L, 859.0 (1.85) U/mL, and 179.27 (1.81) ng/mL, respectively. HRCT showed intralobular interstitial thickening in 9 workers. A dose?response trend was statistically significant for blood KL-6 levels. All workers who had indium levels ≥50 μg/L had KL-6 levels that exceeded the reference values. However, dose?response trends for blood SP-D levels, KL-6 levels, SP-D levels, and interstitial changes on the HRCT scans were not significantly different.
Conclusions: Our findings suggest that interstitial lung changes could be present in workers with indium exposure. Further studies are required and health risk information regarding indium exposure should be communicated to workers and employers in industries where indium compounds are used to prevent indium induced lung damage in Korea.
목차
Abstract
Introduction
Materials and methods
Results
Discussion
Conclusion
References
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Sauler M / 2012 / Newly recognized occupational and environmental causes of chronic terminal airways and parenchymal lung disease / Clin Chest Med 33 : 667 ~ 680
2. [학술지(정기간행물)] - Homma T / 2003 / Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide / J Occup Health 45 : 137 ~ 139
3. [학술지(정기간행물)] - Homma S / 2005 / Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide / Eur Respir J 25 : 200 ~ 204
4. [학술지(정기간행물)] - Cummings KJ / 2010 / Pulmonary alveolar proteinosis in workers at an indium processing facility / Am J Respir Crit Care Med 181 : 458 ~ 464
5. [학술지(정기간행물)] - Cummings KJ / 2012 / Indium lung disease / Chest 141 : 1512 ~ 1521
2. [학술지(정기간행물)] - Homma T / 2003 / Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide / J Occup Health 45 : 137 ~ 139
3. [학술지(정기간행물)] - Homma S / 2005 / Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide / Eur Respir J 25 : 200 ~ 204
4. [학술지(정기간행물)] - Cummings KJ / 2010 / Pulmonary alveolar proteinosis in workers at an indium processing facility / Am J Respir Crit Care Med 181 : 458 ~ 464
5. [학술지(정기간행물)] - Cummings KJ / 2012 / Indium lung disease / Chest 141 : 1512 ~ 1521
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UCI(KEPA) : I410-ECN-0101-2016-517-001952915