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Proteomics in Rheumatoid Arthritis Research
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Type
Academic journal
Author
Yune-Jung Park (The Catholic University) Min Kyung Chung (The Catholic University) Daehee Hwang (Daegu Gyeongbuk Institute of Science and Technology) Wan-Uk Kim (2POSTECH-CATHOLIC)
Journal
The Korean Association of Immunologists Immune Network Vol.15 No.4 KCI Accredited Journals SCIE
Published
2015.8
Pages
177 - 185 (9page)

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Proteomics in Rheumatoid Arthritis Research
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Abstract· Keywords

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Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in the clinical field to assess disease activity and severity. Recently, there has been increasing interest in the discovery of new diagnostic RA biomarkers that can assist in evaluating disease activity, severity, and treatment response. Proteomics, the largescale study of the proteome, has emerged as a powerful technique for protein identification and characterization. For the past 10 years, proteomic techniques have been applied to different biological samples (synovial tissue/fluid, blood, and urine) from RA patients and experimental animal models. In this review, we summarize the current state of the application of proteomics in RA and its importance in identifying biomarkers and treatment targets.
#Rheumatoid arthritis #Proteomics #Biomarker

Contents

INTRODUCTION
PROTEOMICS
EXPLORATION OF NOVEL BIOMARKERS USING A PROTEOMIC APPROACH
CONCLUSION
REFERENCES

References (60)

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[학술지(정기간행물)] - Smolen, J. S. / 2004 / Patients with rheumatoid arthritis in clinical care / Ann. Rheum. Dis 63 : 221 ~ 225 google schola [학술지(정기간행물)] - Wolfe, F. / 2003 / Predicting mortality in patients with rheumatoid arthritis / Arthritis Rheum 48 : 1530 ~ 1542 google schola [학술지(정기간행물)] - Pincus, T. / 1984 / Severe functional declines, work disability, increased mortality in seventy-five rheumatoid arthritis patients studied over nine years / Arthritis Rheum 27 : 864 ~ 872 google schola [학술지(정기간행물)] - Sokka, T. / 2000 / Healing of erosions in rheumatoid arthritis / Ann. Rheum. Dis 59 : 647 ~ 649 google schola [학술지(정기간행물)] - Rau, R. / 2001 / Identification of radiologic healing phenomena in patients with rheumatoid arthritis / J. Rheumatol 28 : 2608 ~ 2615 google schola

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