지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.8
- 수록면
- 148 - 156 (9page)
이용수
초록· 키워드
오류제보하기
The PrP<SUP>C</SUP> is expressed in many types of immune cells including monocytes and macrophages, however, its function in immune regulation remains to be elucidated. In the present study, we examined a role for PrP<SUP>C</SUP> in regulation of monocyte function. Specifically, the effect of a soluble form of PrP<SUP>C</SUP> was studied in human monocytes. A recombinant fusion protein of soluble human PrP<SUP>C</SUP> fused with the Fc portion of human IgG1 (designated as soluble PrP<SUP>C</SUP>-Fc) bound to the cell surface of monocytes, induced differentiation to macrophage-like cells, and enhanced adherence and phagocytic activity. In addition, soluble PrP<SUP>C</SUP>-Fc stimulated monocytes to produce pro-inflammatory
cytokines such as TNF-α, IL-1β, and IL-6. Both ERK and NF-κB signaling pathways were activated in soluble PrP<SUP>C</SUP>-treated monocytes, and inhibitors of either pathway abrogated monocyte adherence and cytokine production. Taken together, we conclude that soluble PrP<SUP>C</SUP>-Fc enhanced adherence, phagocytosis, and cytokine production of monocytes via activation of the ERK and NF-κB signaling pathways.
cytokines such as TNF-α, IL-1β, and IL-6. Both ERK and NF-κB signaling pathways were activated in soluble PrP<SUP>C</SUP>-treated monocytes, and inhibitors of either pathway abrogated monocyte adherence and cytokine production. Taken together, we conclude that soluble PrP<SUP>C</SUP>-Fc enhanced adherence, phagocytosis, and cytokine production of monocytes via activation of the ERK and NF-κB signaling pathways.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Taylor, D. R. / 2006 / The prion protein and lipid rafts / Mol. Membr. Biol 23 : 89 ~ 99
2. [학술지(정기간행물)] - Jackson, G. S. / 2001 / Location and properties of metal-binding sites on the human prion protein / Proc. Natl. Acad. Sci. U. S. A 98 : 8531 ~ 8535
3. [학술지(정기간행물)] - Riek, R. / 1996 / NMR structure of the mouse prion protein domain PrP(121-231) / Nature 382 : 180 ~ 182
4. [학술지(정기간행물)] - Ermonval, M. / 2003 / Evolving views in prion glycosylation: functional and pathological implications / Biochimie 85 : 33 ~ 45
5. [학술지(정기간행물)] - Collinge, J. / 2001 / Prion diseases of humans and animals: their causes and molecular basis / Annu. Rev. Neurosci 24 : 519 ~ 550
2. [학술지(정기간행물)] - Jackson, G. S. / 2001 / Location and properties of metal-binding sites on the human prion protein / Proc. Natl. Acad. Sci. U. S. A 98 : 8531 ~ 8535
3. [학술지(정기간행물)] - Riek, R. / 1996 / NMR structure of the mouse prion protein domain PrP(121-231) / Nature 382 : 180 ~ 182
4. [학술지(정기간행물)] - Ermonval, M. / 2003 / Evolving views in prion glycosylation: functional and pathological implications / Biochimie 85 : 33 ~ 45
5. [학술지(정기간행물)] - Collinge, J. / 2001 / Prion diseases of humans and animals: their causes and molecular basis / Annu. Rev. Neurosci 24 : 519 ~ 550
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-511-001746104